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首页> 外文期刊>Neuron >Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structured activity.
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Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structured activity.

机译：ephrin-As缺乏和结构化活动选择性破坏一个皮层图和感受野的直角坐标轴。

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The topographic representation of visual space is preserved from retina to thalamus to cortex. We have previously shown that precise mapping of thalamocortical projections requires both molecular cues and structured retinal activity. To probe the interaction between these two mechanisms, we studied mice deficient in both ephrin-As and retinal waves. Functional and anatomical cortical maps in these mice were nearly abolished along the nasotemporal (azimuth) axis of the visual space. Both the structure of single-cell receptive fields and large-scale topography were severely distorted. These results demonstrate that ephrin-As and structured neuronal activity are two distinct pathways that mediate map formation in the visual cortex and together account almost completely for the formation of the azimuth map. Despite the dramatic disruption of azimuthal topography, the dorsoventral (elevation) map was relatively normal, indicating that the two axes of the cortical map are organized by separate mechanisms.
机译：从视网膜到丘脑再到皮层，都保留了视觉空间的地形图。我们以前已经表明，丘脑皮质投影的精确映射需要分子提示和结构化的视网膜活性。为了探究这两种机制之间的相互作用，我们研究了缺乏ephrin-As和视网膜波的小鼠。这些小鼠的功能和解剖学皮质图谱沿视觉空间的鼻颞（方位）轴几乎被消除。单细胞感受野和大规模地形的结构都严重扭曲。这些结果表明，ephrin-As和结构化的神经元活性是介导视觉皮层中图谱形成的两个截然不同的途径，几乎一起构成了方位角图谱的形成。尽管方位角地形发生了戏剧性的破坏，但背腹（高程）图还是相对正常的，表明皮质图的两个轴是由单独的机制组织的。

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