Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons.

Tomchik SM; Davis RL

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Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons.

机译：循环AMP成像揭示了昼夜节律神经元中的PDF信号传导。

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In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression.

机译：在果蝇中，昼夜节律需要神经肽PDF，但尚不清楚PDF在何处起作用。在本期《神经元》中，Shafer等人。使用一种新颖的生物成像方法来证明PDF几乎可以升高所有时钟神经元中的cAMP。因此，与先前的PDF受体表达研究相比，PDF显然对生物钟时钟网络产生了更广泛的影响。

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《Neuron》 |2008年第2期|共3页
作者
Tomchik SM; Davis RL;
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原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Animals; Circadian Rhythm; Cyclic AMP; Drosophila Proteins; Neurons; Neuropeptides; 动物; 昼夜节律; 环AMP; 神经元; 神经肽类; 信号传递;

机译：Animals;Circadian Rhythm;Cyclic AMP;Drosophila Proteins;Neurons;Neuropeptides;动物;昼夜节律;环AMP;神经元;神经肽类;信号传递;

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1. Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons. [J] . Tomchik SM, Davis RL Neuron . 2008,第2期

机译：循环AMP成像揭示了昼夜节律神经元中的PDF信号传导。
2. Dual PDF Signaling Pathways Reset Clocks Via TIMELESS and Acutely Excite Target Neurons to Control Circadian Behavior [J] . Adam Seluzicki, Matthieu Flourakis, Elzbieta Kula-Eversole, PLoS Biology . 2014,第3期

机译：双PDF信号通路通过无时限重置时钟并完全激发目标神经元来控制昼夜节律
3. XAP5 CIRCADIAN TIMEKEEPER Coordinates Light Signals for Proper Timing of Photomorphogenesis and the Circadian Clock in Arabidopsis [J] . Martin-Tryon Ellen L, Harmer Stacey L The Plant Cell . 2008,第5期

机译：XAP5 CIRCADIAN TIMEKEEPER协调拟南芥中光形态发生和生物钟的正确时序的光信号。
4. Modeling the mammalian circadian clock with transcriptional feedback loops and cAMP signaling [C] . Wang Junwei, Chen Aimin 2011 30th Chinese Control Conference . 2011

机译：利用转录反馈环和cAMP信号传导对哺乳动物生物钟进行建模
5. Identification of Genomic Targets of Kruppel-like Factor 9 in Mouse Hippocampal Neurons: Evidence for a role in modulating peripheral circadian clocks. [D] . Knoedler, Joseph R. 2016

机译：小鼠海马神经元中Kruppel样因子9的基因组靶标的鉴定：调节外周生物钟的作用的证据。
6. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging [O] . Orie T. Shafer, Dong Jo Kim, Richard Dunbar-Yaffe, -1

机译：实时循环AMP成像揭示果蝇神经元生物钟时钟网络对神经肽PDF的广泛接受性
7. Cyclic AMP Imaging Sheds Light on PDF Signaling in Circadian Clock Neurons [O] . Tomchik Seth M., Davis Ronald L. 2008

机译：循环AMP成像在昼夜节律时钟神经元中为PDF信号提供了参考。

Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons.

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