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首页> 外文期刊>Neuron >NG2(+) CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration.
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NG2(+) CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration.

机译：NG2（+）中枢神经系统神经胶质祖细胞在产后生活和神经退行性变中仍然致力于少突胶质细胞谱系。

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摘要

The mammalian CNS contains a ubiquitous population of glial progenitors known as NG2(+) cells that have the ability to develop into oligodendrocytes and undergo dramatic changes in response to injury and demyelination. Although it has been reported that NG2(+) cells are multipotent, their fate in health and disease remains controversial. Here, we generated PDGFalphaR-CreER transgenic mice and followed their fate in vivo in the developing and adult CNS. These studies revealed that NG2(+) cells in the postnatal CNS generate myelinating oligodendrocytes, but not astrocytes or neurons. In regions of neurodegeneration in the spinal cord of ALS mice, NG2(+) cells exhibited enhanced proliferation and accelerated differentiation into oligodendrocytes but remained committed to the oligodendrocyte lineage. These results indicate that NG2(+) cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors.
机译：哺乳动物的中枢神经系统包含无处不在的神经胶质祖细胞群，称为NG2（+）细胞，它们具有发展为少突胶质细胞并在伤害和脱髓鞘反应中发生显着变化的能力。尽管有报道说NG2（+）细胞具有多能性，但它们在健康和疾病方面的命运仍然存在争议。在这里，我们生成了PDGFalphaR-CreER转基因小鼠，并在发育中和成年中枢神经系统中追踪了它们的体内命运。这些研究表明，产后中枢神经系统中的NG2（+）细胞可产生髓鞘少突胶质细胞，但不会产生星形胶质细胞或神经元。在ALS小鼠的脊髓神经变性区域中，NG2（+）细胞表现出增强的增殖能力，并加速分化为少突胶质细胞，但仍致力于少突胶质细胞谱系。这些结果表明正常的CNS中的NG2（+）细胞是少突胶质细胞前体，谱系潜能有限，并且细胞丢失和神经胶质增生不足以改变这些祖细胞的谱系潜能。

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