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首页> 外文期刊>Neuron >Role of ACh-GABA cotransmission in detecting image motion and motion direction.
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Role of ACh-GABA cotransmission in detecting image motion and motion direction.

机译：ACh-GABA共传输在检测图像运动和运动方向中的作用。

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Starburst amacrine cells (SACs) process complex visual signals in the retina using both acetylcholine (ACh) and gamma-aminobutyric acid (GABA), but the synaptic organization and function of ACh-GABA corelease remain unclear. Here, we show that SACs make cholinergic synapses onto On-Off direction-selective ganglion cells (DSGCs) from all directions but make GABAergic synapses onto DSGCs only from the null direction. ACh and GABA were released differentially in a Ca(2+) level-specific manner, suggesting the two transmitters were released from different vesicle populations. Despite the symmetric cholinergic connection, the light-evoked cholinergic input to a DSGC, detected at both light onset and offset, was motion- and direction-sensitive. This input was facilitated by two-spot apparent motion in the preferred direction but supressed in the null direction, presumably by a GABAergic mechanism. The results revealed a high level of synaptic intricacy in the starburst circuit and suggested differential, yet synergistic, roles of ACh-GABA cotransmission in motion sensitivity and direction selectivity.
机译：爆星无长突细胞（SAC）使用乙酰胆碱（ACh）和γ-氨基丁酸（GABA）处理视网膜中的复杂视觉信号，但ACh-GABA共释放的突触组织和功能仍不清楚。在这里，我们表明，SAC使胆碱能突触从各个方向进入On-Off方向选择性神经节细胞（DSGCs），而使GABA能突触仅从无效方向进入DSGCs。 ACh和GABA以Ca（2+）水平特定的方式差异释放，表明这两种递质是从不同的囊泡群体释放的。尽管存在对称的胆碱能连接，但在光的开始和偏移处检测到的DSGC的光诱发胆碱能输入对运动和方向均敏感。沿首选方向的两点视在运动促进了此输入，但沿零方向被抑制了，这大概是由GABA能机制引起的。结果表明，星爆电路中突触的复杂程度很高，并暗示了ACh-GABA共传递在运动敏感性和方向选择性中的不同但协同作用。

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