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首页> 外文期刊>Neuron >Democracy-Independence Trade-Off in Oscillating Dendrites and Its Implications for Grid Cells
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Democracy-Independence Trade-Off in Oscillating Dendrites and Its Implications for Grid Cells

机译：振荡枝晶中的民主独立权衡及其对网格单元的启示

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Dendritic democracy and independence have been characterized for near-instantaneous processing of synaptic inputs. However, a wide class of neuronal computations requires input integration on long timescales. As a paradigmatic example, entorhinal grid fields have been thought to be generated by the democratic summation of independent dendritic oscillations performing direction-selective path integration. We analyzed how multiple dendritic oscillators embedded in the same neuron integrate inputs separately and determine somatic membrane voltage jointly. We found that the interaction of dendritic oscillations leads to phase locking, which sets an upper limit on the timescale for independent input integration. Factors that increase this timescale also decrease the influence that the dendritic oscillations exert on somatic voltage. In entorhinal stellate cells, interdendritic coupling dominates and causes these cells to act as single oscillators. Our results suggest a fundamental trade-off between local and global processing in dendritic trees integrating ongoing signals.
机译：树突式民主和独立性的特征是突触输入的近乎瞬时处理。但是，各种各样的神经元计算都需要长时间的输入集成。作为一个典型的例子，内嗅网格域被认为是由独立的树突状振荡的民主求和产生的，该独立的树突状振荡执行方向选择路径积分。我们分析了嵌入在同一神经元中的多个树突状振荡器如何分别集成输入并共同确定体膜电压。我们发现，树突振荡的相互作用导致锁相，这为独立输入积分的时间范围设置了上限。增加该时间尺度的因素还减少了树突振荡对体电压施加的影响。在内嗅星状细胞中，树突间耦合起主导作用，并使这些细胞充当单个振荡器。我们的结果表明，树突树中整合了持续信号的本地处理和全局处理之间存在根本的权衡。

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