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首页> 外文期刊>Neuron >Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor.
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Drosophila Nedd4, a ubiquitin ligase, is recruited by Commissureless to control cell surface levels of the roundabout receptor.

机译：果蝇Nedd4是一种遍在蛋白连接酶，由Commissureless募集来控制回旋受体的细胞表面水平。

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摘要

Crossing the midline produces changes in axons such that they are no longer attracted to the midline. In Drosophila, Roundabout reaches high levels on axons once they have crossed the midline, and this prohibits recrossing. Roundabout protein levels are regulated by Commissureless. We show that Commissureless binds to and is regulated by the ubiquitin ligase DNedd4. We further show that the ability of Commissureless to regulate Roundabout protein levels requires an intact DNedd4 binding site and ubiquitin acceptor sites within the Commissureless protein. The ability of Commissureless to regulate Robo in the embryo also requires a Commissureless/DNedd4 interaction. Our results show that changes in axonal sensitivity to external cues during pathfinding across the midline makes use of ubiquitin-dependent mechanisms to regulate transmembrane protein levels.
机译：越过中线会产生轴突变化，以使它们不再被中线所吸引。在果蝇中，回旋处一旦越过中线，轴突的水平就会很高，这将阻止回旋。回旋处的蛋白质水平受委员会的监管。我们显示，Communcureless与泛素连接酶DNedd4结合并受其调控。我们进一步表明，Communsureless调节Roundabout蛋白水平的能力需要完整的DNedd4结合位点和Commissureless蛋白内的泛素受体位点。 Commissureless调节胚胎中Robo的能力还需要Commissureless / DNedd4相互作用。我们的结果表明，在穿越中线的寻路过程中，轴突对外部线索的敏感性变化利用了泛素依赖性机制来调节跨膜蛋白水平。

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