Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.

Bagri Anil; Marin Oscar; Plump AndrewS; Mak Judy; Pleasure SamuelJ; Rubenstein-JohnL R; Tessier-Lavigne Marc

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Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.

机译：狭缝蛋白可防止中线交叉并确定哺乳动物前脑中主要轴突途径的背腹位置。

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We report that Slit proteins, a family of secreted chemorepellents, are crucial for the proper development of several major forebrain tracts. Mice deficient in Slit2 and, even more so, mice deficient in both Slit1 and Slit2 show significant axon guidance errors in a variety of pathways, including corticofugal, callosal, and thalamocortical tracts. Analysis of multiple pathways suggests several generalizations regarding the functions of Slit proteins in the brain, which appear to contribute to (1) the maintenance of dorsal position by prevention of axonal growth into ventral regions, (2) the prevention of axonal extension toward and across the midline, and (3) the channeling of axons toward particular regions.

机译：我们报告说，裂隙蛋白是一种分泌的化学趋化剂，对于几个主要的前脑束的正常发育至关重要。 Slit2缺乏的小鼠，甚至Slit1和Slit2均缺乏的小鼠在多种途径中均表现出明显的轴突引导错误，包括皮质漏斗，愈伤组织和丘脑皮质。多种途径的分析提出了关于脑中Slit蛋白功能的几种概括，这似乎有助于（1）通过防止轴突生长进入腹侧区来维持背侧位置，（2）防止轴突向和跨过轴突延伸。中线;（3）轴突向特定区域的引导。

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来源
《Neuron》 |2002年第2期|共16页
作者
Bagri Anil; Marin Oscar; Plump AndrewS; Mak Judy; Pleasure SamuelJ; Rubenstein-JohnL R; Tessier-Lavigne Marc;
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正文语种 eng
中图分类神经生理学;
关键词
Axons; Nerve Tissue Proteins; Prosencephalon; Receptors; Immunologic; Slit1-protein; 轴突; 神经组织蛋白质类; 前脑;

机译：Axons;Nerve Tissue Proteins;Prosencephalon;Receptors;Immunologic;Slit1-protein;轴突;神经组织蛋白质类;前脑;

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1. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. [J] . Bagri Anil, Marin Oscar, Plump AndrewS, Neuron . 2002,第2期

机译：狭缝蛋白可防止中线交叉并确定哺乳动物前脑中主要轴突途径的背腹位置。
2. Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. [J] . Lopez-Bendito G, Flames N, Ma L, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2007,第13期

机译：Robo1和Robo2合作以控制哺乳动物前脑中主要轴突的引导。
3. Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. [J] . Lopez-Bendito G, Flames N, Ma L, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2007,第13期

机译：Robo1和Robo2合作以控制哺乳动物前脑中主要轴突的引导。
4. Genome-scale RNA interference screen identifies key pathways and genes for improving recombinant protein production in mammalian cells [C] . Su Xiao, Yu Chi Chen, Eugene Buehler, Cell culture engineering XV . 2016

机译：基因组规模的RNA干扰筛选可识别关键途径和基因，以改善哺乳动物细胞中重组蛋白的产生
5. Mammalian road crossing patterns along a major highway within Adirondack Park of New York State, USA. [D] . LaPoint, Scott Daniel. 2007

机译：沿一条主要高速公路的哺乳动物的平交道口样式在纽约州，美国阿迪朗达克公园内。
6. Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing [O] . Atsushi Tamada, Tatsuro Kumada, Yan Zhu, 2008

机译：Robo蛋白在小脑轴突中线穿越中的关键作用及其在中线穿越后缺乏上调的作用
7. Slit proteins prevent midline crossing and determine dorsoventral position of major axonal pathways in the mammalian forebrain [O] . Bagri, A., Marín Parra, Óscar, Plump, A. S., 2002

机译：狭缝蛋白可防止中线交叉并确定哺乳动物前脑中主要轴突途径的背腹位置

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.

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