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首页> 外文期刊>Neuron >State-dependent heterogeneity in synaptic depression between pyramidal cell pairs.
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State-dependent heterogeneity in synaptic depression between pyramidal cell pairs.

机译：锥体细胞对之间突触抑制中状态依赖的异质性。

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摘要

Paired recordings between CA3 pyramidal neurons were used to study the properties of synaptic plasticity in active and silent synapses. Synaptic depression is accompanied by decreases in both AMPAR and NMDAR function. The mechanisms of synaptic depression, and the potential to undergo activity-dependent plastic changes in efficacy, differ depending on whether a synapse is active, recently silent, or potentiated. These results suggest that silent and active synapses represent distinct synaptic "states," and that once unsilenced, synapses express plasticity in a graded manner. The state in which a synapse resides, and the states recently visited, determine its potential and mechanism for undergoing subsequent plastic changes.
机译：CA3锥体神经元之间的配对记录用于研究主动和沉默突触中突触可塑性的特性。突触抑制伴随着AMPAR和NMDAR功能的降低。突触抑制的机制以及功效发生活动性可塑性变化的可能性，取决于突触是活跃的，最近沉默的还是增强的。这些结果表明沉默和主动突触代表不同的突触“状态”，并且一旦不沉默，突触以分级的方式表达可塑性。突触所在的状态以及最近访问的状态确定了其发生后续塑性变化的潜力和机制。

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