首页> 外文期刊>Neuron >Afferent growth cone interactions control synaptic specificity in the Drosophila visual system.
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Afferent growth cone interactions control synaptic specificity in the Drosophila visual system.

机译:传入的生长锥相互作用控制果蝇视觉系统中的突触特异性。

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摘要

In the Drosophila compound eye, photoreceptors (R cells) that respond to light from the same point in space are distributed across the retina and connect to the same target neurons. This complex connectivity pattern reconstructs visual space in the first optic ganglion, the lamina. We have used mutations that delete specific R cell subtypes or alter their retinal organization to define the cellular mechanisms that generate this pattern. R cell axons are programmed to search for targets within a local region in the lamina but their selection of appropriate postsynaptic targets requires specific interactions among R cell growth cones. The orientation of the projections is controlled both by the spatial arrangement of R cells in the retina and by cues in the target.
机译:在果蝇复眼中,对来自空间同一点的光做出响应的感光细胞(R细胞)分布在整个视网膜上,并连接到相同的目标神经元。这种复杂的连通性模式可在第一个视神经节(椎板)中重建视觉空间。我们已经使用了删除特定R细胞亚型或改变其视网膜组织的突变来定义产生这种模式的细胞机制。 R细胞轴突被编程为搜索层中局部区域内的靶标,但是要选择合适的突触后靶标,则需要R细胞生长锥之间进行特定的相互作用。投影的方向既受视网膜中R细胞的空间排列,又受靶中的提示控制。

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