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首页> 外文期刊>Neuron >Amphetamine modulates human incentive processing.
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Amphetamine modulates human incentive processing.

机译:苯丙胺调节人的激励过程。

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摘要

Research suggests that psychostimulants can physiologically alter dopamine kinetics in the ventral striatum (VS) and psychologically enhance mood and attention. Using event-related functional magnetic resonance imaging (fMRI), we conducted a within-subject, double-blind, placebo (PLAC)-controlled study of the effects of oral dextroamphetamine (AMPH, 0.25 mg/kg) treatment on brain activity and affect during incentive processing. In two counterbalanced scanning sessions 60-180 min after ingesting AMPH or PLAC, 8 healthy volunteers played a game involving anticipation and receipt of monetary gains and losses. Group and volume of interest analyses suggested that by enhancing tonic over phasic activation, AMPH treatment "equalized" levels of VS activity and positive arousal during anticipation of both gain and loss. These findings suggest that therapeutic effects of amphetamine on incentive processing may involve reducing the difference between anticipation of gains and losses.
机译:研究表明,精神兴奋剂可以在生理上改变腹侧纹状体(VS)中的多巴胺动力学,并在心理上增强情绪和注意力。使用事件相关的功能磁共振成像(fMRI),我们进行了一项受试者内部,双盲,安慰剂(PLAC)对照研究,研究口服右旋苯丙胺(AMPH,0.25 mg / kg)对大脑活动和情绪的影响在激励过程中。在摄取AMPH或PLAC后60-180分钟的两次平衡扫描过程中,有8位健康的志愿者玩了一场游戏,其中涉及金钱收益和损失的预期和接收。感兴趣的组和量分析表明,通过增强补品,使其超过阶段性激活,AMPH治疗可“平衡” VS活性水平,并在预期获得和丧失过程中引起积极的唤醒。这些发现表明,苯丙胺对激励过程的治疗作用可能涉及减少收益与损失预期之间的差异。

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