Pruning an axon piece by piece: a new mode of synapse elimination.

Koirala S; Ko CP

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Pruning an axon piece by piece: a new mode of synapse elimination.

机译：逐步修剪轴突：一种新的突触消除模式。

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The process by which excess axons are pruned during development has remained unclear. In this issue of Neuron, Bishop et al. use time-lapse imaging and serial electron microscopy of developing neuromuscular junctions to describe a novel cellular mechanism in which retracting axon branches shed fragments rich in normal synaptic organelles. These axosomes into the glial cytoplasm. Shedding of axosomes and glial engulfment may represent a widespread mechanism of synapse elimination.

机译：在开发过程中修剪多余轴突的过程仍不清楚。在本期《神经元》中，Bishop等人。使用延时成像和发展中的神经肌肉连接的连续电子显微镜来描述一种新型的细胞机制，其中缩回的轴突分支会脱落富含正常突触细胞器的片段。这些轴突进入胶质细胞质。轴突的脱落和神经胶质吞噬可能代表了广泛的突触消除机制。

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《Neuron》 |2004年第4期|共3页
作者
Koirala S; Ko CP;
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正文语种 eng
中图分类基础医学;
关键词
Axons; Neuromuscular Junction; Peripheral Nervous System; Synapses; 轴突; 神经肌肉接头; 周围神经系统; 突触;

机译：Axons;Neuromuscular Junction;Peripheral Nervous System;Synapses;轴突;神经肌肉接头;周围神经系统;突触;

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1. Pruning an axon piece by piece: a new mode of synapse elimination. [J] . Koirala S, Ko CP Neuron . 2004,第4期

机译：逐步修剪轴突：一种新的突触消除模式。
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3. Developmental expression profiles of axon guidance signaling and the immune system in the marmoset cortex: Potential molecular mechanisms of pruning of dendritic spines during primate synapse formation in late infancy and prepuberty (I) [J] . SasakiT., OgaT., NakagakiK., Biochemical and Biophysical Research Communications . 2014,第3期

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6. GABA Signaling Promotes Synapse Elimination and Axon Pruning in Developing Cortical Inhibitory Interneurons [O] . Xiaoyun Wu, Yu Fu, Graham Knott, 2012

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7. Pruning an Axon Piece by Piece A New Mode of Synapse Elimination [O] . Koirala Samir, Ko Chien-Ping 2004

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8. Recovery of Piece-Wise Planar and Piece-Wise Rigid Models from Non-Rigid Motion [R] . Alon, J. , Sclaroff, S. 1999

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Pruning an axon piece by piece: a new mode of synapse elimination.

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