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首页> 外文期刊>Neuron >The neuroanatomy of remote memory.
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The neuroanatomy of remote memory.

机译：远程记忆的神经解剖学。

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In humans and experimental animals, damage to the hippocampus or related medial temporal lobe structures severely impairs the formation of new memory but typically spares very remote memory. Questions remain about the importance of these structures for the storage and retrieval of remote autobiographical memory. We carried out a detailed volumetric analysis of structural brain images from eight memory-impaired patients. Five of the patients had damage limited mainly to the medial temporal lobe. These patients performed normally on tests of remote autobiographical memory. Three patients had medial temporal lobe damage plus significant additional damage to neocortex, and these patients were severely impaired. These findings account for previously reported differences in the recollective ability of memory-impaired patients and demonstrate that the ability to recollect remote autobiographical events depends not on the medial temporal lobe but on widely distributed neocortical areas, especially the frontal,lateral temporal, and occipital lobes.
机译：在人类和实验动物中，对海马或相关的颞叶内侧结构的损害严重损害了新记忆的形成，但通常会保留非常远的记忆。这些结构对于存储和检索远程自传存储器的重要性仍然存在疑问。我们对八名记忆障碍患者的脑结构图像进行了详细的体积分析。其中五名患者的损害主要限于颞中叶。这些患者通常进行远程自传体记忆检查。三名患者的颞叶内侧受损，另外还对新皮层造成了明显的额外损害，这些患者严重受损。这些发现解释了先前报道的记忆力受损患者的记忆力差异，并证明了恢复远端自传事件的能力并不取决于内侧颞叶，而取决于广泛分布的新皮质区域，尤其是额叶，外侧颞叶和枕叶。

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