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首页> 外文期刊>Neuron >A 'sample-and-hold' pulse-counting integrator as a mechanism for graded memory underlying sensorimotor adaptation.
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A 'sample-and-hold' pulse-counting integrator as a mechanism for graded memory underlying sensorimotor adaptation.

机译：一种“采样保持”脉冲计数积分器，作为一种基于感觉运动适应的分级记忆的机制。

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摘要

The mechanisms behind the induction of cellular correlates of memory by sensory input and their contribution to meaningful behavioral changes are largely unknown. We previously reported a graded memory in the form of sensorimotor adaptation in the electromotor output of electric fish. Here we show that the mechanism for this adaptation is a synaptically induced long-lasting shift in intrinsic neuronal excitability. This mechanism rapidly integrates hundreds of spikes in a second, or gradually integrates the same number of spikes delivered over tens of minutes. Thus, this mechanism appears immune to frequency-dependent fluctuations in input and operates as a simple pulse counter over a wide range of time scales, enabling it to transduce graded sensory information into a graded memory and a corresponding change in the behavioral output. This adaptation is based on an NMDA receptor-mediated change in intrinsic excitability of the postsynaptic neurons involving the Ca2+-dependent activation of TRP channels.
机译：很大程度上尚不清楚通过感觉输入诱导记忆的细胞相关性背后的机制及其对有意义的行为改变的贡献。我们先前曾以电鱼的电动机输出中的感觉运动适应形式报告了分级记忆。在这里，我们表明这种适应的机制是内在神经元兴奋性的突触诱导的持久转变。这种机制可以在一秒钟内快速集成数百个尖峰，或者逐渐集成数十分钟内交付的相同数量的尖峰。因此，这种机制似乎不受输入频率依赖的波动的影响，并且可以在很宽的时间范围内作为简单的脉冲计数器运行，从而使其能够将分级的感官信息转换为分级的记忆，以及行为输出的相应变化。这种适应是基于NMDA受体介导的突触后神经元固有兴奋性的变化，其中涉及Ca2 +依赖的TRP通道的激活。

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