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首页> 外文期刊>Neuron >PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.
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PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling.

机译：PDGFRα阳性B细胞是成年SVZ中的神经干细胞，响应PDGF信号的增加而形成神经胶质瘤样生长。

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摘要

Neurons and oligodendrocytes are produced in the adult brain subventricular zone (SVZ) from neural stem cells (B cells), which express GFAP and have morphological properties of astrocytes. We report here on the identification B cells expressing the PDGFRalpha in the adult SVZ. Specifically labeled PDGFRalpha expressing B cells in vivo generate neurons and oligodendrocytes. Conditional ablation of PDGFRalpha in a subpopulation of postnatal stem cells showed that this receptor is required for oligodendrogenesis, but not neurogenesis. Infusion of PDGF alone was sufficient to arrest neuroblast production and induce SVZ B cell proliferation contributing to the generation of large hyperplasias with some features of gliomas. The work demonstrates that PDGFRalpha signaling occurs early in the adult stem cell lineage and may help regulate the balance between oligodendrocyte and neuron production. Excessive PDGF activation in the SVZ in stem cells is sufficient to induce hallmarks associated with early stages oftumor formation.
机译：神经元和少突胶质细胞是在成年脑室下区（SVZ）中由神经干细胞（B细胞）产生的，它们表达GFAP并具有星形胶质细胞的形态特性。我们在这里报告在成年SVZ中表达PDGFRalpha的识别B细胞。体内特异性标记的表达PDGFRalpha的B细胞产生神经元和少突胶质细胞。产后干细胞亚群中PDGFRalpha的条件消融表明，该受体是少突胶质生成所必需的，但不是神经生成所必需的。单独注入PDGF足以阻止神经母细胞的产生并诱导SVZ B细胞增殖，从而促进具有神经胶质瘤某些特征的大型增生的产生。这项工作表明，PDGFRalpha信号发生在成年干细胞谱系的早期，可能有助于调节少突胶质细胞和神经元产生之间的平衡。干细胞中SVZ中的PDGF过度活化足以诱导与肿瘤形成早期相关的标志。

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