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首页> 外文期刊>Neuron >Sensory neurons in the Drosophila genital tract regulate female reproductive behavior.
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Sensory neurons in the Drosophila genital tract regulate female reproductive behavior.

机译:果蝇生殖道中的感觉神经元调节女性生殖行为。

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摘要

Females of many animal species behave very differently before and after mating. In Drosophila melanogaster, changes in female behavior upon mating are triggered by the sex peptide (SP), a small peptide present in the male's seminal fluid. SP activates a specific receptor, the sex peptide receptor (SPR), which is broadly expressed in the female reproductive tract and nervous system. Here, we pinpoint the action of SPR to a small subset of internal sensory neurons that innervate the female uterus and oviduct. These neurons express both fruitless (fru), a marker for neurons likely to have sex-specific functions, and pickpocket (ppk), a marker for proprioceptive neurons. We show that SPR expression in these fru+ ppk+ neurons is both necessary and sufficient for behavioral changes induced by mating. These neurons project to regions of the central nervous system that have been implicated in the control of reproductive behaviors in Drosophila and other insects.
机译:许多动物的雌性在交配之前和之后的行为都大不相同。在果蝇中,雌性交配时雌性行为的变化是由性肽(SP)触发的,该性肽是雄性精液中的一种小肽。 SP激活一种特异性受体,即性肽受体(SPR),在女性生殖道和神经系统中广泛表达。在这里,我们将SPR的作用精确定位到支配女性子宫和输卵管的一小部分内部感觉神经元。这些神经元既表达无果(fru),这是可能具有性别特异性功能的神经元的标志物,又是扒手(ppk),是本体感受性神经元的标志物。我们表明,在这些fru + ppk +神经元中的SPR表达对于交配引起的行为变化既必要又足够。这些神经元投射到中枢神经系统区域,这些区域与果蝇和其他昆虫的生殖行为控制有关。

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