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首页> 外文期刊>Neuron >The actions of synaptically released zinc at hippocampal mossy fiber synapses.
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The actions of synaptically released zinc at hippocampal mossy fiber synapses.

机译：突触释放锌在海马苔藓纤维突触中的作用。

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摘要

Zn2+ is present at high concentrations in the synaptic vesicles of hippocampal mossy fibers. We have used Zn2+ chelators and the mocha mutant mouse to address the physiological role of Zn2+ in this pathway. Zn2+ is not involved in the unique presynaptic plasticities observed at mossy fiber synapses but is coreleased with glutamate from these synapses, both spontaneously and with electrical stimulation, where it exerts a strong modulatory effect on the NMDA receptors. Zn2+ tonically occupies the high-affinity binding site of NMDA receptors at mossy fiber synapses, whereas the lower affinity voltage-dependent Zn2+ binding site is occupied during action potential driven-release. We conclude that Zn2+ is a modulatory neurotransmitter released from mossy fiber synapses and plays an important role in shaping the NMDA receptor response at these synapses.
机译：Zn2 +以高浓度存在于海马苔藓纤维的突触小泡中。我们已经使用了Zn2 +螯合剂和mocha突变小鼠来解决Zn2 +在该途径中的生理作用。 Zn2 +并不参与在苔藓纤维突触中观察到的独特的突触前可塑性，但会自发地或通过电刺激与这些突触中的谷氨酸共释放，从而对NMDA受体发挥强大的调节作用。 Zn2 +在苔藓纤维突触处在色调上占据NMDA受体的高亲和力结合位点，而较低的亲和力电压依赖性Zn2 +结合位点在动作电位驱动释放过程中占据。我们得出的结论是，Zn2 +是从生苔纤维突触释放的调节性神经递质，在塑造这些突触处的NMDA受体反应中起重要作用。

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