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首页> 外文期刊>Neuron >Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.
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Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA.

机译：果蝇二酰基甘油激酶突变体rdgA中光敏通道TRP和TRPL的组成活性。

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摘要

Mutations in the Drosophila retinal degeneration A (rdgA) gene, which encodes diacylglycerol kinase (DGK), result in early onset retinal degeneration and blindness. Whole-cell recordings revealed that light-sensitive Ca2+ channels encoded by the trp gene were constitutively active in rdgA photoreceptors. Early degeneration was rescued in rdgA;trp double mutants, lacking TRP channels; however, the less Ca2+-permeable light-sensitive channels (TRPL) were constitutively active instead. No constitutive activity was seen in rdgA;trpI;trp mutants lacking both classes of channel, although, like rdgA;trp, these still showed a residual slow degeneration. Responses to light were restored in rdgA;trp but deactivated abnormally slowly, indicating that DGK is required for response termination. The findings suggest that early degeneration in rdgA is caused by uncontrolled Ca2+ influx and support the proposal that diacylglycerol or its metabolites are messengers of excitation in Drosophila photoreceptors.
机译：果蝇视网膜变性A（rdgA）基因中的突变编码双酰基甘油激酶（DGK），可导致视网膜视网膜变性和失明。全细胞记录显示，由trp基因编码的光敏Ca2 +通道在rdgA感光器中具有组成性活性。 rdgA; trp双重突变体，缺乏TRP通道，挽救了早期变性。但是，Ca2 +渗透性较低的光敏通道（TRPL）却具有本构活性。在缺少两种通道的rdgA; trpI; trp突变体中均未观察到组成性活性，尽管与rdgA; trp一样，这些突变体仍显示出残留的缓慢变性。对光的响应在rdgA; trp中得以恢复，但异常缓慢地失活，表明响应终止需要DGK。这些发现表明，rdgA的早期变性是由不受控制的Ca2 +流入引起的，并支持了二酰基甘油或其代谢物是果蝇感光器激发的信使的提议。

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