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首页> 外文期刊>Neuron >A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
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A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.

机译：Rho相关激酶p160ROCK在确定哺乳动物CNS神经元轴突生长中的关键作用。

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摘要

We tested the contribution of the small GTPase Rho and its downstream target p160ROCK during the early stages of axon formation in cultured cerebellar granule neurons. p160ROCK inhibition, presumably by reducing the stability of the cortical actin network, triggered immediate outgrowth of membrane ruffles and filopodia, followed by the generation of initial growth cone-ike membrane domains from which axonal processes arose. Furthermore, a potentiation in both the size and the motility of growth cones was evident, though the overall axon elongation rate remained stable. Conversely, overexpression of dominant active forms of Rho or ROCK was suggested to prevent initiation of axon outgrowth. Taken together, our data indicate a novel role for the Rho/ROCK pathway as a gate critical for the initiation of axon outgrowth and the control of growth cone dynamics.
机译：我们测试了小GTPase Rho及其下游目标p160ROCK在培养的小脑颗粒神经元轴突形成早期的贡献。 p160ROCK的抑制作用可能是通过降低皮质肌动蛋白网络的稳定性而引起的，从而引起膜皱纹和丝状伪足的迅速生长，随后产生了最初的生长锥状膜结构域，并由此产生了轴突过程。此外，虽然总体轴突伸长率保持稳定，但生长锥的大小和运动性均得到了增强。相反，Rho或ROCK的主要活性形式的过表达被认为可以防止轴突生长。两者合计，我们的数据表明Rho / ROCK通路作为轴突生长的起始和生长锥动力学控制的关键门的新型作用。

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