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首页> 外文期刊>Neuron >arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity.
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arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity.

机译：arouser揭示了突触数在乙醇敏感性调节中的作用。

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摘要

A reduced sensitivity to the sedating effects of alcohol is a characteristic associated with alcohol use disorders (AUDs). A genetic screen for ethanol sedation mutants in Drosophila identified arouser (aru), which functions in developing neurons to reduce ethanol sensitivity. Genetic evidence suggests that aru regulates ethanol sensitivity through its activation by Egfr/Erk signaling and its inhibition by PI3K/Akt signaling. The aru mutant also has an increased number of synaptic terminals in the larva and adult fly. Both the increased ethanol sensitivity and synapse number of the aru mutant are restored upon adult social isolation, suggesting a causal relationship between synapse number and ethanol sensitivity. We thus show that a developmental abnormality affecting synapse number and ethanol sensitivity is not permanent and can be reversed by manipulating the environment of the adult fly. VIDEO ABSTRACT:
机译：对酒精镇静作用的敏感性降低是与酒精使用障碍（AUD）相关的特征。果蝇乙醇镇静突变体的遗传筛选确定了唤醒剂（aru），其在发育神经元中起作用以降低乙醇敏感性。遗传证据表明aru通过Egfr / Erk信号激活和PI3K / Akt信号抑制抑制乙醇敏感性。 aru突变体在幼虫和成年蝇中的突触末端数量也增加。成年社会隔离后，aru突变体增加的乙醇敏感性和突触数量都恢复，这表明突触数量与乙醇敏感性之间存在因果关系。因此，我们表明影响突触数量和乙醇敏感性的发育异常不是永久性的，可以通过操纵成年苍蝇的环境来逆转。视频摘要：

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