Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia.

Antonov I; Antonova I; Kandel ER; Hawkins RD

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Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia.

机译：依赖于活动的突触前促进和Hebbian LTP都是必需的，并且在海狸鼠的经典调节过程中会相互作用。

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Using a simplified preparation of the Aplysia siphon-withdrawal reflex, we previously found that associative plasticity at synapses between sensory neurons and motor neurons contributes importantly to classical conditioning of the reflex. We have now tested the roles in that plasticity of two associative cellular mechanisms: activity-dependent enhancement of presynaptic facilitation and postsynaptically induced long-term potentiation. By perturbing molecular signaling pathways in individual neurons, we have provided the most direct evidence to date that each of these mechanisms contributes to behavioral learning. In addition, our results suggest that the two mechanisms are not independent but rather interact through retrograde signaling.

机译：使用Aplysia虹吸撤回反射的简化制备方法，我们先前发现，感觉神经元和运动神经元之间的突触的缔合可塑性对反射的经典调节起重要作用。现在，我们已经测试了两种关联细胞机制在可塑性中的作用：突触前促进的活动依赖性增强和突触后诱导的长期增强。通过扰动单个神经元中的分子信号传导途径，我们提供了迄今为止最直接的证据，表明这些机制均有助于行为学习。此外，我们的结果表明这两种机制不是独立的，而是通过逆行信号相互作用的。

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《Neuron》 |2003年第1期|共13页
作者
Antonov I; Antonova I; Kandel ER; Hawkins RD;
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原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Conditioning; Classical; Aplysia; plasticity; Endurance of activity; Facilitation; 条件反射; 经典; 海螺;

机译：Conditioning;Classical;Aplysia;plasticity;Endurance of activity;Facilitation;条件反射;经典;海螺;

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1. Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia. [J] . Antonov I, Antonova I, Kandel ER, Neuron . 2003,第1期

机译：依赖于活动的突触前促进和Hebbian LTP都是必需的，并且在海狸鼠的经典调节过程中会相互作用。
2. Essential role of presynaptic NMDA receptors in activity-dependent BDNF secretion and corticostriatal LTP [J] . ParkH., PopescuA., PooM.-M. Neuron . 2014,第5期

机译：突触前NMDA受体在活动依赖的BDNF分泌和皮质上皮LTP中的重要作用。
3. Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses. [J] . Zakharenko SS, Patterson SL, Dragatsis I, Neuron . 2003,第6期

机译：突触前BDNF是海马CA1-CA3突触中LTP的突触前但不是突触后成分所必需的。
4. Temporal Hebbian Learning in Rate-Coded Neural Networks: A Theoretical Approach towards Classical Conditioning [C] . Bernd Porr, Florentin Worgotter International Conference on Artificial Neural Networks . 2001

机译：速率编码神经网络中的颞备学习：古典调理的理论方法
5. A PKM generated by calpain cleavage of a classical PKC is required for activity-dependent intermediate-term facilitation in the presynaptic sensory neuron of Aplysia [O] . Carole A. Farah, Margaret H. Hastings, Tyler W. Dunn, 2017

机译：钙蛋白酶裂解经典PKC产生的PKM是海葵突触前感觉神经元活动依赖性中期促进的必需条件
6. Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia [O] . Antonov Igor, Antonova Irina, Kandel Eric R., 2003

机译：依赖于活动的突触前促进和Hebbian LTP是必需的，并且在海狸鼠的经典条件下会相互作用

Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia.

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