...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Unique roles of SK and Kv4.2 potassium channels in dendritic integration.
【24h】

Unique roles of SK and Kv4.2 potassium channels in dendritic integration.

机译：SK和Kv4.2钾通道在树突整合中的独特作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Focal activation of glutamate receptors in distal dendrites of hippocampal pyramidal cells triggers voltage-dependent Ca(2+) channel-mediated plateau potentials that are confined to the stimulated dendrite. We examined the role of dendritic K(+) conductances in determining the amplitude, duration, and spatial compartmentalization of plateau potentials. Manipulations that blocked SK-type Ca(2+)-activated K(+) channels, including apamin and BAPTA dialysis, increased the duration of plateau potentials without affecting their amplitude or compartmentalization. Manipulations that blocked Kv4.2 A-type K(+) channels, including a dominant-negative Kv4.2 construct and 4-aminopyridine, increased the amplitude of plateau potentials by allowing them to recruit neighboring dendrites. Prolongation of plateau potentials or block of Kv4.2 channels at branch points facilitated the ability of dendritic excitation to trigger fast action potentials. SK channels thus underlie repolarization of dendritic plateau potentials,whereas Kv4.2 channels confine these potentials to single dendritic branches, and both act in concert to regulate synaptic integration.
机译：谷氨酸受体在海马锥体细胞的远端树突中的焦点激活触发电压依赖性Ca（2+）通道介导的平台电位，其局限于被刺激的树突。我们检查了树突状K（+）电导在确定振幅，持续时间和高原电位的空间区划中的作用。阻止SK型Ca（2+）激活K（+）通道，包括阿帕明和BAPTA透析的操作增加了高原电位的持续时间，而不会影响其振幅或分隔。阻止Kv4.2 A型K（+）通道（包括显性负Kv4.2构建体和4-氨基吡啶）的操作通过允许它们募集邻近的树突而增加了高原电位的幅度。平台电位的延长或分支点Kv4.2通道的阻滞促进了树突激发触发快速动作电位的能力。因此，SK通道是树突状平台电位复极化的基础，而Kv4.2通道则将这些电位限制在单个树突状分支中，并且两者协同作用以调节突触整合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号