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首页> 外文期刊>Neuron >Direction-selective dendritic action potentials in rabbit retina.
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Direction-selective dendritic action potentials in rabbit retina.

机译:兔视网膜中的方向选择性树突动作电位。

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摘要

Dendritic spikes that propagate toward the soma are well documented, but their physiological role remains uncertain. Our in vitro patch-clamp recordings and two-photon calcium imaging show that direction-selective retinal ganglion cells (DSGCs) utilize orthograde dendritic spikes during physiological activity. DSGCs signal the direction of image motion. Excitatory subthreshold postsynaptic potentials are observed in DSGCs for motion in all directions and provide a weakly tuned directional signal. However, spikes are generated over only a narrow range of motion angles, indicating that spike generation greatly enhances directional tuning. Our results indicate that spikes are initiated at multiple sites within the dendritic arbors of DSGCs and that each dendritic spike initiates a somatic spike. We propose that dendritic spike failure, produced by local inhibitory inputs, might be a critical factor that enhances directional tuning of somatic spikes.
机译:朝向体细胞传播的树突状棘突已有充分文献记载,但其生理作用仍不确定。我们的体外膜片钳记录和双光子钙成像显示,方向选择性视网膜神经节细胞(DSGC)在生理活动过程中利用了正级树突状棘突。 DSGC发出图像运动方向的信号。在DSGC中观察到兴奋性亚阈值突触后电位,可以在所有方向上运动,并提供微弱的方向信号。但是,仅在狭窄的运动角度范围内产生尖峰,这表明尖峰的产生极大地增强了方向调谐。我们的结果表明,尖峰是在DSGC的树突状乔木中的多个位置引发的,每个树突状尖峰都会引发体细胞的尖峰。我们建议由局部抑制性输入产生的树突状突波破坏可能是增强体细胞突波定向调整的关键因素。

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