Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases.

Cheung ZH; Fu AK; Ip NY

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Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases.

机译：Cdk5的突触作用：在更高的认知功能和神经退行性疾病中的意义。

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Accumulating evidence indicates that cyclin dependent kinase 5 (Cdk5), through phosphorylating a plethora of pre- and postsynaptic proteins, functions as an essential modulator of synaptic transmission. Recent advances in the field of Cdk5 research have not only consolidated the in vivo importance of Cdk5 in neurotransmission but also suggest a pivotal role of Cdk5 in the regulation of higher cognitive functions and neurodegenerative diseases. In this review, we will discuss the recent findings on the emanating role of Cdk5 as a regulator of synaptic functions and plasticity.

机译：越来越多的证据表明，细胞周期蛋白依赖性激酶5（Cdk5）通过使大量的突触前和突触后蛋白磷酸化，充当突触传递的重要调节剂。 Cdk5研究领域的最新进展不仅巩固了Cdk5在神经传递中的体内重要性，而且表明Cdk5在调节更高的认知功能和神经退行性疾病中起关键作用。在这篇综述中，我们将讨论有关Cdk5作为突触功能和可塑性调节剂的作用的最新发现。

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《Neuron》 |2006年第1期|共6页
作者
Cheung ZH; Fu AK; Ip NY;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
Cognition; Cyclin-Dependent Kinase 5; Neurodegenerative Diseases; Synapses; 认知; 神经变性疾病; 突触;

机译：Cognition;Cyclin-Dependent Kinase 5;Neurodegenerative Diseases;Synapses;认知;神经变性疾病;突触;

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1. Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases. [J] . Cheung ZH, Fu AK, Ip NY Neuron . 2006,第1期

机译：Cdk5的突触作用：在更高的认知功能和神经退行性疾病中的意义。
2. The role of sleep in regulating structural plasticity and synaptic strength: Implications for memory and cognitive function [J] . Raven Frank, Van der Zee Eddy A., Meerlo Peter, Sleep medicine reviews . 2018,第期

机译：睡眠在调节结构可塑性和突触强度方面的作用：对记忆和认知功能的影响
3. Mechanisms mediating brain and cognitive reserve: experience-dependent neuroprotection and functional compensation in animal models of neurodegenerative diseases. [J] . Nithianantharajah J, Hannan AJ Progress in Neuro-Psychopharmacology & Biological Psychiatry: An International Research, Review and News Journal . 2011,第2期

机译：介导大脑和认知储备的机制：在神经退行性疾病的动物模型中依赖经验的神经保护和功能补偿。
4. Possible Biological And Cognitive Functions Of Neural Networks Probabilistically Driven By An Influence Of Probabilistic Release Of Synaptic Vesicles [C] . Tsuda, I. Engineering in Medicine and Biology Society, 1990., Proceedings of the Twelfth Annual International Conference of the IEEE . 1990

机译：突触小泡的概率释放影响可能驱动的神经网络的可能的生物学和认知功能
5. Roles of Syngap Isoforms in Synaptic and Cognitive Functions [D] . Kilinc, Murat. 2019

机译：Syngap同种型在突触和认知功能中的角色
6. Regulation of Hippocampal Synaptic Function by the Metabolic Hormone Leptin: Implications for Health and Neurodegenerative Disease [O] . Gemma McGregor, Jenni Harvey 2018

机译：代谢激素瘦素对海马突触功能的调节：对健康和神经退行性疾病的影响
7. Synaptic roles of Cdk5: Implications in higher cognitive functions and neurodegenerative diseases [O] . Cheung, ZH, Fu, AKY, Ip, NY 2006

机译：Cdk5的突触作用：对更高的认知功能和神经退行性疾病的影响

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases.

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