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首页> 外文期刊>Neuron >Selectivity of neuronal adaptation does not match response selectivity: a single-cell study of the FMRI adaptation paradigm.
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Selectivity of neuronal adaptation does not match response selectivity: a single-cell study of the FMRI adaptation paradigm.

机译：神经元适应的选择性与反应选择性不匹配：FMRI适应范例的单细胞研究。

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摘要

fMRI-based adaptation paradigms (fMR-A) have been used to infer neuronal stimulus selectivities in humans. Inferring neuronal selectivities from fMR-A, however, requires an understanding of the relationship between the stimulus selectivity of neuronal adaptation and responses. We studied this relationship by recording single cells in macaque inferior temporal (IT) cortex, an area that shows fMRI adaptation. Repetition of identical object images reduced the responsiveness of single IT neurons. Presentation of an image to which the neuron was unresponsive did not alter the response to a subsequent image that activated the neuron. Successive presentation of two different images to which the neuron responded similarly produced adaptation, but less so than the repeated presentation of an image. The neuronal adaptation at the single-cell level showed a greater degree of stimulus selectivity than the responses. This complicates the interpretation of fMR-A paradigms when inferring neuronal selectivity.
机译：基于功能磁共振成像的适应范例（fMR-A）已被用于推断人类神经元刺激的选择性。然而，从fMR-A推断神经元选择性需要了解神经元适应的刺激选择性与反应之间的关系。我们通过在猕猴下颞叶（IT）皮层（显示fMRI适应性的区域）中记录单个细胞来研究这种关系。重复相同的对象图像会降低单个IT神经元的响应能力。呈现神经元无反应的图像不会改变对激活神经元的后续图像的响应。神经元对其响应的两个不同图像的连续呈现类似地产生了适应，但是不像图像的重复呈现那样。与反应相比，单细胞水平的神经元适应表现出更大程度的刺激选择性。当推断神经元选择性时，这会使fMR-A范例的解释复杂化。

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