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首页> 外文期刊>Neuron >Translation of sensory input into behavioral output via an olfactory system.
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Translation of sensory input into behavioral output via an olfactory system.

机译：通过嗅觉系统将感觉输入转化为行为输出。

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摘要

We investigate the logic by which sensory input is translated into behavioral output. First we provide a functional analysis of the entire odor receptor repertoire of an olfactory system. We construct tuning curves for the 21 functional odor receptors of the Drosophila larva and show that they sharpen at lower odor doses. We construct a 21-dimensional odor space from the responses of the receptors and find that the distance between two odors correlates with the extent to which one odor masks the other. Mutational analysis shows that different receptors mediate the responses to different concentrations of an odorant. The summed response of the entire receptor repertoire correlates with the strength of the behavioral response. The activity of a small number of receptors is a surprisingly powerful predictor of behavior. Odors that inhibit more receptors are more likely to be repellents. Odor space is largely conserved between two dissimilar olfactory systems.
机译：我们研究了将感觉输入转化为行为输出的逻辑。首先，我们提供嗅觉系统整个气味受体库的功能分析。我们为果蝇幼虫的21种功能性气味受体构建了调谐曲线，并显示它们在较低的气味剂量下会变尖锐。我们根据受体的响应构建了一个21维的气味空间，发现两种气味之间的距离与一种气味掩盖另一种气味的程度相关。突变分析表明，不同的受体介导了对不同浓度的气味剂的响应。整个受体库的总反应与行为反应的强度相关。少数受体的活性是行为的令人惊讶地有力的预测因子。抑制更多受体的气味更可能是驱蚊剂。在两个不同的嗅觉系统之间，气味空间在很大程度上得以保留。

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