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首页> 外文期刊>Neuron >Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion.
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Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion.

机译：开关方向选择性视网膜神经节细胞亚型的遗传鉴定揭示了后运动的特定层皮层下图。

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Motion detection is an essential component of visual processing. On-Off direction-selective retinal ganglion cells (On-Off DSGCs) detect objects moving along specific axes of the visual field due to their precise retinal circuitry. The brain circuitry of On-Off DSGCs, however, is largely unknown. We report a mouse with GFP expressed selectively by the On-Off DSGCs that detect posterior motion (On-Off pDSGCs), allowing two-photon targeted recordings of their light responses and delineation of their complete map of central connections. On-Off pDSGCs project exclusively to the dorsal lateral geniculate nucleus and superior colliculus and in both targets form synaptic lamina that are separate from a lamina corresponding to non-DSGCs. Thus, individual On-Off DSGC subtypes are molecularly distinct and establish circuits that map specific qualities of directional motion to dedicated subcortical areas. This suggests that each RGC subtype represents a unique parallel pathway whose synaptic specificity in the retina is recapitulated in central targets.
机译：运动检测是视觉处理的重要组成部分。开-关方向选择性视网膜神经节细胞（开-关DSGC）由于其精确的视网膜电路，可以检测沿特定视场轴移动的对象。然而，开关式DSGC的大脑电路在很大程度上是未知的。我们报告的老鼠与GFP由开-关DSGC选择性地表达，检测后运动（开-关pDSGCs），允许其光响应的两个光子靶向记录和描绘他们完整的中央连接图。 On-Off pDSGCs仅投射到背外侧膝状核和上丘，并且在两个靶标中均形成突触层，这些层与对应于非DSGC的层分开。因此，各个开关DSGC亚型在分子上是不同的，并建立了将定向运动的特定质量映射到专用皮层下区域的电路。这表明每个RGC亚型代表一个独特的平行途径，其视网膜突触特异性在中央靶标中得以概括。

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