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首页> 外文期刊>Neuron >Lesion mapping of cognitive abilities linked to intelligence.
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Lesion mapping of cognitive abilities linked to intelligence.

机译：与智力相关的认知能力的病灶图。

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The Wechsler Adult Intelligence Scale (WAIS) assesses a wide range of cognitive abilities and impairments. Factor analyses have documented four underlying indices that jointly comprise intelligence as assessed with the WAIS: verbal comprehension (VCI), perceptual organization (POI), working memory (WMI), and processing speed (PSI). We used nonparametric voxel-based lesion-symptom mapping in 241 patients with focal brain damage to investigate their neural underpinnings. Statistically significant lesion-deficit relationships were found in left inferior frontal cortex for VCI, in left frontal and parietal cortex for WMI, and in right parietal cortex for POI. There was no reliable single localization for PSI. Statistical power maps and cross-validation analyses quantified specificity and sensitivity of the index scores in predicting lesion locations. Our findings provide comprehensive lesion maps of intelligence factors, and make specific recommendations for interpretation and application of the WAIS to the study of intelligence in health and disease.
机译：韦氏成人智力量表（WAIS）评估了广泛的认知能力和障碍。因子分析已记录了四个基本指标，这些指标由WAIS评估共同构成了智力：语言理解（VCI），感知组织（POI），工作记忆（WMI）和处理速度（PSI）。我们对241例局灶性脑损伤患者使用了基于非参数体素的病变症状图谱，以研究其神经基础。在VCI的左下额叶皮层，WMI的左额叶和顶叶皮层以及POI的右顶叶皮层中发现了统计学上显着的病变缺损关系。 PSI没有可靠的单一本地化。统计功率图和交叉验证分析在预测病变位置时量化了指标得分的特异性和敏感性。我们的发现提供了综合的智力因素病变图，并为WAIS在健康和疾病智力研究中的解释和应用提出了具体建议。

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