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首页> 外文期刊>Neuron >Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment
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Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

机译：减少海马多动症可改善轻度认知障碍的认知

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摘要

Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal models have indicated that overactivity in selective hippocampal circuits contributes to cognitive impairment. Here, we tested the effect of reducing hippocampal activation in aMCI. Under placebo treatment, hippocampal activation in the dentate gyrus/CA3 was elevated in aMCI patients compared to a healthy control group. By using a low dose of the antiepileptic levetiracetam hippocampal activation in aMCI was reduced to a level that did not differ from the control group. Compared to aMCI memory performance under placebo, performance in the scanning task was significantly improved under drug treatment. Contrary to the view that greater hippocampal activation might serve a beneficial function, these results support the view that increased hippocampal activation in aMCI is a dysfunctional condition and that targeting excess hippocampal activity has therapeutic potential.
机译：在赋予阿尔茨海默氏病风险的条件下，包括失忆性轻度认知障碍（aMCI），观察到海马激活水平升高。在相关动物模型中的研究表明，选择性海马回路中的过度活动会导致认知障碍。在这里，我们测试了减少aMCI中海马激活的效果。在安慰剂治疗下，与健康对照组相比，aMCI患者的齿状回/ CA3的海马激活增加。通过使用低剂量的抗癫痫药左乙拉西坦，aMCI中的海马激活降低至与对照组无差异的水平。与安慰剂下的aMCI记忆性能相比，药物治疗下扫描任务的性能得到了显着改善。与更大的海马激活可能起有益作用的观点相反，这些结果支持这样的观点，即aMCI中海马激活的增加是功能失调的状况，而针对过量海马活性的靶向治疗具有治疗潜力。

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