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首页> 外文期刊>NeuroImage >Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: an emotional linguistic goo-go fMRI study.
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Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: an emotional linguistic goo-go fMRI study.

机译：情绪刺激处理和运动抑制控制相互作用的神经基质：一项情绪语言的去/不去功能磁共振成像研究。

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摘要

Neural substrates of behavioral inhibitory control have been probed in a variety of animal model, physiologic, behavioral, and imaging studies, many emphasizing the role of prefrontal circuits. Likewise, the neurocircuitry of emotion has been investigated from a variety of perspectives. Recently, neural mechanisms mediating the interaction of emotion and behavioral regulation have become the focus of intense study. To further define neurocircuitry specifically underlying the interaction between emotional processing and response inhibition, we developed an emotional linguistic goo-go fMRI paradigm with a factorial block design which joins explicit inhibitory task demand (i.e., go or no-go) with task-unrelated incidental emotional stimulus valence manipulation, to probe the modulation of the former by the latter. In this study of normal subjects focusing on negative emotional processing, we hypothesized activity changes in specific frontal neocortical and limbic regions reflecting modulation of response inhibition by negative stimulus processing. We observed common fronto-limbic activations (including orbitofrontal cortical and amygdalar components) associated with the interaction of emotional stimulus processing and response suppression. Further, we found a distributed cortico-limbic network to be a candidate neural substrate for the interaction of negative valence-specific processing and inhibitory task demand. These findings have implications for elucidating neural mechanisms of emotional modulation of behavioral control, with relevance to a variety of neuropsychiatric disease states marked by behavioral dysregulation within the context of negative emotional processing.
机译：在各种动物模型，生理，行为和影像学研究中都探究了行为抑制控制的神经基质，其中许多研究都强调了额额前回路的作用。同样，已经从多种角度研究了情绪的神经回路。近年来，介导情绪与行为调节相互作用的神经机制已成为深入研究的重点。为了进一步定义特定于情绪处理和反应抑制之间相互作用的神经回路，我们开发了一种情感语言的去/不去功能磁共振成像范式，其阶乘模块设计将明确的抑制性任务需求（即去或不去）与任务-无关的偶然情绪刺激价操纵，以探讨前者对后者的调节。在这项针对负面情绪加工的正常受试者的研究中，我们假设特定额叶新皮质和边缘区的活动变化反映了负面刺激加工对反应抑制的调节作用。我们观察到与情绪刺激处理和反应抑制的相互作用相关的常见的额前边缘激活（包括眶额叶皮质和杏仁核成分）。此外，我们发现分布式皮质-边缘网络是负价特异性加工与抑制任务需求相互作用的候选神经底物。这些发现对阐明行为控制的情绪调节的神经机制具有重要意义，这与在负面情绪加工的背景下以行为失调为特征的多种神经精神疾病有关。

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