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首页> 外文期刊>Neuropeptides: An International Journal >Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: relation to anxiety-like and depressive-like behavior.
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Increased CRF-like and NPY-like immunoreactivity in adult rats exposed to nicotine during adolescence: relation to anxiety-like and depressive-like behavior.

机译：在青春期暴露于尼古丁的成年大鼠中，CRF样和NPY样免疫反应性增加：与焦虑样和抑郁样行为有关。

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OBJECTIVE: Recently, animal models have been developed that demonstrate that adolescent nicotine exposure produces neurobehavioral changes which persist into adulthood. This study further examined the impact of adolescent nicotine exposure on anxiety-like and depressive-like behavior, as well as on levels of corticotropin-releasing factor (CRF) and neuropeptide Y (NPY) in this model. METHODS: Male adolescent rats (35-40 days old) were administered nicotine using Nicoderm CQ patches (Smith-Kline Beecham). Behavior in the elevated plus maze (EPM) and forced swim test (FST) was assessed 2-3 weeks after exposure ended. Brain levels of CRF and NPY were then assessed 5-6 weeks after behavioral tests were completed. In addition, blood and brain levels of nicotine resulting from nicotine treatment were examined. RESULTS: After 5 days of exposure to 5 mg/kg/day nicotine, blood levels of nicotine averaged 66+/-5 ng/ml and brain nicotine levels averaged 52+/-4 ng/g. Rats exposed to nicotine displayed an anxiety-like profile in the EPM (i.e., decreased time spent in the open arms) and an antidepressant-like profile in the FST (i.e., less time spent immobile). Rats exposed to nicotine also had increased hypothalamic and frontal cortical CRF, increased hypothalamic and hippocampal NPY, and a decreased ratio of NPY to CRF in the amygdala. CONCLUSIONS: This study demonstrates that adolescent nicotine exposure produces lasting increases in anxiety-like behavior and may reduce depressive-like behavior. These behavioral changes also occurred in concert with alterations in CRF and NPY systems. Thus, lasting neurobehavioral changes associated with adolescent nicotine exposure may be related to allostatic changes in stress peptide systems.
机译：目的：最近已经开发出动物模型，证明青少年尼古丁暴露会引起神经行为改变，并持续到成年期。这项研究进一步检查了青少年尼古丁暴露对该模型中焦虑样和抑郁样行为以及促肾上腺皮质激素释放因子（CRF）和神经肽Y（NPY）水平的影响。方法：使用Nicoderm CQ贴片（Smith-Kline Beecham）对雄性青春期大鼠（35-40天大）进行尼古丁给药。暴露结束后2-3周评估高架迷宫（EPM）和强迫游泳测试（FST）的行为。然后在行为测试完成后5-6周评估大脑的CRF和NPY水平。另外，检查了由尼古丁治疗引起的血液和脑中尼古丁水平。结果：暴露于5 mg / kg /天的尼古丁5天后，尼古丁的血液平均水平为66 +/- 5 ng / ml，脑部尼古丁的平均水平为52 +/- 4 ng / g。暴露于尼古丁的大鼠在EPM中表现出焦虑状（即，张开双臂的时间减少），而在FST中表现出抗抑郁状的表现（即，较少的静止时间）。暴露于尼古丁的大鼠杏仁体下丘脑和额叶皮层CRF也升高，下丘脑和海马NPY升高，NPY与CRF的比例降低。结论：这项研究表明，青少年尼古丁暴露会持续增加焦虑样行为，并可能减少抑郁样行为。这些行为变化也与CRF和NPY系统的变化共同发生。因此，与青少年尼古丁暴露相关的持久神经行为改变可能与应激肽系统中的同素异形变化有关。

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