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首页> 外文期刊>Neuropeptides: An International Journal >Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model.
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Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model.

机译：在福尔马林疼痛模型中，脑室内施用的吗啡和β-内啡肽使上丘脑NMDA和非NMDA受体差异地参与了抗伤害感受的产生。

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Our previous studies have demonstrated that supraspinal glutamate receptors are differentially involved in the antinociception induced by morphine and beta-endorphin given intracerebroventricularly (i.c.v.) in the tail-flick and hot-plate tests. The formalin pain test was used in the present study. Injection of mice with formalin solution (2%, 10 microl) into the hindpaw intraplantarly produced the first (0-5 min) and second (20-40 min) phases of formalin responses. The formalin responses in the both phases were attenuated dose-dependently by morphine (0.125-1 microg) or beta-endorphin (0.125-1 microg) administered i.c.v. 5 min before. The antinociceptive effect of morphine was slightly more potent in the second phase whereas the effect of beta-endorphin was more pronounced in the first phase. MK-801 (0.1-1 microg), a non-competitive NMDA receptor antagonist, and CNQX (0.05-0.5 microg), a non-NMDA antagonist, given i.c.v., produced antinociceptive effect in the both phases, but only in a partial manner. Both MK-801 (0.05 microg) and CNQX (0.01 microg), at the dose which had no intrinsic effect, reversed the antinociceptive effect of beta-endorphin (1 microg) observed during the second, but not the first, phase partially but significantly. However, the antinociceptive effect of morphine (1 microg) was not affected by the same dose of MK-801 or CNQX given i.c.v. Our results indicate that, at the supraspinal level, both NMDA and non-NMDA receptors are involved in the production of antinociception induced by supraspinally administered beta-endorphin, but not morphine, in the formalin pain model. Copyright 2000 Harcourt Publishers Ltd.
机译：我们以前的研究表明，在甩尾和热板试验中，脑室内（i.c.v.）给予吗啡和β-内啡肽诱导的脊髓上皮谷氨酸受体与镇痛作用不同。在本研究中使用了福尔马林疼痛测试。用福尔马林溶液（2％，10微升）将小鼠福尔马林注射入足爪后，产生福尔马林反应的第一阶段（0-5分钟）和第二阶段（20-40分钟）。静脉内注射吗啡（0.125-1微克）或β-内啡肽（0.125-1微克）可剂量依赖性减弱这两个阶段的福尔马林反应。 5分钟前。吗啡的抗伤害作用在第二阶段稍强，而β-内啡肽的作用在第一阶段更为明显。给定icv的非竞争性NMDA受体拮抗剂MK-801（0.1-1微克）和非NMDA拮抗剂CNQX（0.05-0.5微克）在这两个阶段均产生了抗伤害感受性，但仅部分产生。在没有内在作用的剂量下，MK-801（0.05微克）和CNQX（0.01微克）均可逆转在第二阶段（而非第一阶段）观察到的β-内啡肽（1微克）的抗伤害感受作用，部分但明显。但是，吗啡（1微克）的镇痛作用不受静脉内注射相同剂量的MK-801或CNQX的影响。我们的结果表明，在脊髓上水平，在福尔马林疼痛模型中，NMDA和非NMDA受体均参与由经脊髓上施用的β-内啡肽（而非吗啡）诱导的抗伤害感受的产生。版权所有2000 Harcourt Publishers Ltd.。

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