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首页> 外文期刊>Neuropharmacology >Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine.
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Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine.

机译：MPEP对可卡因或吗啡诱导的运动，敏化和条件奖励的影响。

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Exposure to environmental cues is considered a major cause of relapse in detoxified addicts. Recent findings showed an involvement of glutamate in cue-induced relapse and suggest that subtype 5 of metabotropic glutamate receptors (mGluR5) is involved in conditioned drug-reward. The present study applied the conditioned place preference (CPP) paradigm to examine the involvement of mGluR5 in cocaine- and morphine-induced behaviours. Results of previous mice-studies were extended into rats by using the selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP). As a result, the evaluated behavioural parameters were dose-relatedly affected by MPEP. Low-dosed MPEP (10 mg/kg, i.p.) did not affect spontaneous locomotion, reduced cocaine-induced hyperlocomotion and produced sensitized locomotion, while showing no effect on sensitized locomotion induced by repeated cocaine or morphine. Low-dosed MPEP did not genuinely block development of cocaine- and morphine-CPP, but rendered CPP expression state-dependent. The medium MPEP-dose (30 mg/kg) was most effective in reducing spontaneous locomotion. The high MPEP-dose (50 mg/kg) was most effective in reducing both body-weight and morphine-CPP expression. Cocaine-CPP expression was not affected by any MPEP-dose. In conclusion, mGluR5 are involved in modulation of spontaneous and cocaine-induced locomotion, in state-dependent learning and in expression of morphine-CPP. Thus, MPEP may be beneficial for relapse prevention in morphine-addicts.
机译：暴露于环境提示被认为是戒毒成瘾者复发的主要原因。最近的发现表明谷氨酸参与提示诱导的复发，并提示代谢型谷氨酸受体的亚型5（mGluR5）参与条件药物奖励。本研究应用条件性位置偏爱（CPP）范例来检查mGluR5在可卡因和吗啡诱导的行为中的参与。通过使用选择性mGluR5拮抗剂2-甲基-6-（苯基乙炔基）吡啶（MPEP），将先前的小鼠研究的结果扩展到大鼠中。结果，所评估的行为参数受到MPEP剂量相关的影响。低剂量MPEP（10 mg / kg，i.p.）不会影响自发运动，减少可卡因诱导的运动过度并产生致敏运动，但对反复可卡因或吗啡引起的致敏运动没有影响。低剂量MPEP并未真正阻止可卡因和吗啡CPP的发育，但使CPP表达呈状态依赖性。 MPEP中等剂量（30 mg / kg）在减少自发运动方面最有效。高MPEP剂量（50 mg / kg）在降低体重和吗啡CPP表达方面最有效。可卡因-CPP表达不受任何MPEP剂量的影响。总之，mGluR5参与自发和可卡因诱导的运动的调节，状态依赖型学习和吗啡-CPP的表达。因此，MPEP对于吗啡成瘾者的预防复发可能是有益的。

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