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首页> 外文期刊>Neuropharmacology >5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354.
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5-HT has contrasting effects in the frontal cortex, but not the hypothalamus, on changes in noradrenaline efflux induced by the monoamine releasing-agent, d-amphetamine, and the reuptake inhibitor, BTS 54 354.

机译：5-HT在额叶皮层具有相反的作用，但对下丘脑没有影响，这是由单胺释放剂d-苯异丙胺和再摄取抑制剂BTS 54354引起的去甲肾上腺素外流变化的影响。

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There is extensive evidence for functional interactions between central noradrenergic and serotonergic neurones. Here, dual-probe microdialysis was used in freely-moving rats to compare the effects of 5-HT on noradrenergic transmission in the rat frontal cortex and hypothalamus. We studied the effects of the 5-HT synthesis inhibitor, para-chlorophenylalanine (pCPA; which depleted 5-HT stores in both the frontal cortex and the hypothalamus), on spontaneous efflux of noradrenaline and on the noradrenergic responses to d-amphetamine, and the monoamine reuptake inhibitor, BTS 54 354. pCPA pretreatment alone did not affect spontaneous noradrenaline efflux in either brain region, whether or not alpha2-autoreceptors were inactivated by administration of the alpha2-antagonist, atipamezole (1 mg/kg i.p). However, in the frontal cortex, pCPA pretreatment augmented the amplitude of, and prolonged, the noradrenergic response to local infusion of d-amphetamine (10 microM). In contrast, pCPA abolished the increase in cortical noradrenaline efflux induced by local infusion of BTS 54 354 (50 microM). In the hypothalamus, pCPA did not affect the amplitude of the response to either of these agents but did prolong the effects of d-amphetamine on noradrenaline efflux. These findings suggest that serotonergic transmission has complex effects on the noradrenergic response to drugs that increase noradrenergic transmission in the frontal cortex, but has less influence in the hypothalamus.
机译：有大量证据表明中枢去甲肾上腺素能和血清素能神经元之间存在功能性相互作用。在这里，双探针微透析用于自由活动的大鼠，以比较5-HT对大鼠额叶皮质和下丘脑中去甲肾上腺素能传递的影响。我们研究了5-HT合成抑制剂对氯苯丙氨酸（pCPA;耗尽了额叶皮层和下丘脑中的5-HT储存）对去甲肾上腺素的自发外流以及对去甲苯丙胺的去甲肾上腺素能的反应的影响，以及单胺再摄取抑制剂，BTS 54354。单独进行pCPA预处理不会影响任何一个大脑区域的自发去甲肾上腺素外排，无论是否通过给予α2拮抗药阿替帕唑（1 mg / kg ip）使α2自身受体失活。但是，在额叶皮层中，pCPA预处理增加了去甲肾上腺素（10 microM）局部输注的去甲肾上腺素能反应的幅度，并延长了其持续时间。相反，pCPA消除了局部输注BTS 54 354（50 microM）引起的皮质去甲肾上腺素外流的增加。在下丘脑中，pCPA不会影响对任何一种药物的反应幅度，但会延长d-苯异丙胺对去甲肾上腺素外排的影响。这些发现表明，血清素能传递对去甲肾上腺素能响应的药物具有复杂的作用，该药物增加额叶皮层的去甲肾上腺素能传递，但对下丘脑的影响较小。

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