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Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic

机译：杆菌素生物合成的生物化学，遗传学和调控及其意义远胜于抗生素

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摘要

Bacillus subtilis has the capacity to produce more than two dozen bioactive compounds with an amazing variety of chemical structures. Among them, bacilysin is a non-ribosomally synthesized dipeptide antibiotic consisting of L-alanine residue at the N terminus and a non-proteinogenic amino acid, L-anticapsin, at the C terminus. In spite of its simple structure, it is active against a wide range of bacteria and fungi. As a potent antimicrobial agent, we briefly review the biochemistry and genetics as well as the regulation of bacilysin biosynthesis within the frame of peptide pheromones-based control of secondary activities. Biological functions of bacilysin in the producer B. subtilis beyond its antimicrobial activity as well as potential biotechnological use of the biosynthetic enzyme L-amino acid ligase (Lal) are also discussed.
机译：枯草芽孢杆菌具有生产超过二十种具有令人惊奇的化学结构的生物活性化合物的能力。其中，杆菌肽溶血素是一种非核糖体合成的二肽抗生素，由N端的L-丙氨酸残基和C端的非蛋白氨基酸L-anticapsin组成。尽管其结构简单，但它对多种细菌和真菌具有活性。作为一种有效的抗菌剂，我们在基于肽信息素的次级活性控制框架内简要回顾了生物化学和遗传学以及芽胞溶素生物合成的调控。还讨论了芽孢杆菌溶菌素在生产枯草芽孢杆菌中的生物学功能，以及其抗菌活性以及生物合成酶L-氨基酸连接酶（Lal）的潜在生物技术用途。

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