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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Brain aging in humans, chimpanzees (pan troglodytes), and rhesus macaques (macaca mulatta): Magnetic resonance imaging studies of macro- and microstructural changes
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Brain aging in humans, chimpanzees (pan troglodytes), and rhesus macaques (macaca mulatta): Magnetic resonance imaging studies of macro- and microstructural changes

机译：人类，黑猩猩（泛穴居动物）和猕猴（猕猴）的大脑老化：宏观和微观结构变化的磁共振成像研究

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Among primates, humans are uniquely vulnerable to many age-related neurodegenerative disorders. We used structural and diffusion magnetic resonance imaging (MRI) to examine the brains of chimpanzees and rhesus monkeys across each species' adult lifespan, and compared these results with published findings in humans. As in humans, gray matter volume decreased with age in chimpanzees and rhesus monkeys. Also like humans, chimpanzees showed a trend for decreased white matter volume with age, but this decrease occurred proportionally later in the chimpanzee lifespan than in humans. Diffusion MRI revealed widespread age-related decreases in fractional anisotropy and increases in radial diffusivity in chimpanzees and macaques. However, both the fractional anisotropy decline and the radial diffusivity increase started at a proportionally earlier age in humans than in chimpanzees. Thus, even though overall patterns of gray and white matter aging are similar in humans and chimpanzees, the longer lifespan of humans provides more time for white matter to deteriorate before death, with the result that some neurological effects of aging may be exacerbated in our species.
机译：在灵长类动物中，人类特别容易受到许多与年龄相关的神经退行性疾病的伤害。我们使用结构和扩散磁共振成像（MRI）来检查每个物种成年寿命中黑猩猩和恒河猴的大脑，并将这些结果与人类已发表的发现进行比较。与人类一样，黑猩猩和恒河猴的灰质体积随着年龄的增长而减少。与人类一样，黑猩猩也显示出随着年龄增长白质数量减少的趋势，但是这种减少在黑猩猩的寿命中成比例地发生在人类之后。扩散MRI显示，黑猩猩和猕猴的年龄各向异性普遍降低，而径向扩散系数增加。但是，人类的分数各向异性下降和径向扩散率的增加都比黑猩猩成比例地开始于人类。因此，即使人类和黑猩猩的灰色和白色物质衰老的总体模式相似，人类更长的寿命也为死亡前的白色物质恶化提供了更多的时间，结果在我们的物种中可能会加剧某些衰老的神经系统影响。

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