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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Infiltration of the brain by pathogens causes Alzheimer's disease.
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Infiltration of the brain by pathogens causes Alzheimer's disease.

机译：病原体浸润大脑会导致阿尔茨海默氏病。

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Despite very numerous studies on Alzheimer's disease (AD), especially on amyloid plaques and neurofibrillary tangles, little information has been obtained thus on the causes of the disease. Evidence is described here that implicates firstly herpes simplex virus type 1 (HSV1) as a strong risk factor when it is present in brain of carriers of the type 4 allele of the gene for apolipoprotein E (APOE-4). Indirect support comes from studies indicating the role of APOE in several diverse diseases of known pathogen cause. A second putative risk factor is the bacterium, Chlamydia pneumoniae. This pathogen has been identified and localized in AD brain. Current studies aimed at "proof of principle" address the entry of the organism into the CNS, the neuroinflammatory response to the organism, and the role that the organism plays in triggering AD pathology. An infection-based animal model demonstrates that following intranasal inoculation of BALB/c mice with C. pneumoniae, amyloid plaques/deposits consistent withthose observed in the AD brain develop, thus implicating this infection in the etiology of AD.
机译：尽管关于阿尔茨海默氏病（AD），特别是淀粉样蛋白斑块和神经原纤维缠结的研究非常多，但是关于该病的原因却知之甚少。此处描述的证据表明，当载脂蛋白E（APOE-4）基因的4型等位基因携带者的脑中存在单纯疱疹病毒1型（HSV1）时，它是强烈的危险因素。间接支持来自研究，这些研究表明APOE在几种已知病原体引起的多种疾病中的作用。第二个假定的危险因素是细菌，肺炎衣原体。该病原体已被鉴定并定位在AD脑中。目前针对“原理证明”的研究涉及生物体进入中枢神经系统，对生物体的神经炎症反应以及生物体在触发AD病理学中的作用。基于感染的动物模型表明，鼻内接种肺炎衣原体后，BALB / c小鼠会出现与在AD脑中观察到的淀粉样斑块/沉积物一致的沉积，从而将这种感染与AD的病因相关。

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