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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease.
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Evidence supporting a role for anti-Abeta antibodies in the treatment of Alzheimer's disease.

机译：支持抗Abeta抗体在阿尔茨海默氏病治疗中起作用的证据。

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摘要

Antibodies against Abeta have been suggested as potential therapeutic strategies for the treatment of Alzheimer disease (AD) for nearly 8 years. Animal studies have been very encouraging in that both active and passive immunization of transgenic mice can reduce amyloid load and reverse memory deficits found in these mice. Three mechanisms have been proposed to explain these results: (a). catalytic conversion of fibrillar Abeta to less toxic forms, (b). opsonization of Abeta deposits leading to microglial phagocytosis, or (c). promote the efflux of Abeta from the brain to the circulation. Evidence exists supporting all three mechanisms, which, it should be noted, are not mutually exclusive. Phase 2 clinical trials of active immunization with vaccines against human Abeta1-42 were halted due to an unacceptable incidence of meningoencephalitic reactions (6% of patients treated). However, a recent report from a fraction of the patients in this trial found that those patients developing antibodies which reacted with brain amyloid deposits had a significantly slower progression of cognitive loss over a period of 12 months. This supports the continued cautious testing of passive immunization and, possibly even active immunization against the Abeta peptide using preparations less likely to cause autoimmune reactions in the central nervous system.
机译：已经提出，针对Abeta的抗体已作为治疗阿尔茨海默氏病（AD）的潜在疗法近8年。动物研究非常令人鼓舞，因为主动和被动免疫转基因小鼠均可减少淀粉样蛋白负荷并逆转这些小鼠中发现的记忆缺陷。提出了三种机制来解释这些结果：（a）。将原纤维Abeta催化转化为毒性较低的形式，（b）。 Abeta沉积物的调理作用导致小胶质细胞吞噬，或（c）。促进Abe​​ta从大脑到血液循环。有证据支持所有这三种机制，应当指出，这并不是相互排斥的。由于脑膜脑病反应的发生率不可接受（接受治疗的患者的6％），因此停止了针对人Abeta1-42疫苗的主动免疫的2期临床试验。但是，该试验中有一部分患者的最新报告发现，那些与脑淀粉样蛋白沉积物发生反应的抗体患者在12个月内认知丧失的进程明显减慢。这支持继续谨慎测试被动免疫，甚至可能使用不太可能在中枢神经系统中引起自身免疫反应的制剂对Abeta肽进行主动免疫。

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