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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Increased NGF proforms in aged sympathetic neurons and their targets.
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Increased NGF proforms in aged sympathetic neurons and their targets.

机译：老年交感神经元及其靶标中NGF形式的增加。

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摘要

Target-derived neurotrophins such as nerve growth factor (NGF) and neurotrophin-3 (NT-3) regulate sympathetic neuron survival. Here, NGF and NT-3 protein and transcript were examined in sympathetic neurons and targets in order to determine their role in age-related neuronal atrophy. One obvious alteration was a dramatic increase (up to 50-fold) in NGF protein forms, corresponding to proNGF-B, in the superior cervical ganglion (SCG) and targets where sympathetic innervation shows atrophy. In the iris, where sympathetic innervation is protected into old age, proNGF-B was decreased. Alterations in NGF transcript paralleled changes in NGF protein, albeit to a lesser degree. Though significantly increased in aged SCG, NT-3 protein, found primarily as the 'mature' form, showed only minor changes in most tissues, though NT-3 mRNA generally was decreased. In contrast, both NT-3 transcript and NT-3 precursors were increased in iris. The dramatic increases in proNGF, together with minimal changes in NT-3, suggest that alterations in NGF regulation may contribute to the loss of sympathetic innervation observed in many aged peripheral targets.
机译：目标来源的神经营养蛋白，例如神经生长因子（NGF）和Neurotrophin-3（NT-3）调节交感神经元的存活。在这里，在交感神经元和目标中检查了NGF和NT-3蛋白和转录本，以确定它们在与年龄有关的神经元萎缩中的作用。一个明显的改变是上颈神经节（SCG）和交感神经支配显示萎缩的靶标中，与proNGF-B相对应的NGF蛋白形式急剧增加（最多50倍）。在虹膜中，交感神经受保护直至老年，proNGF-B降低。 NGF转录物的变化与NGF蛋白的变化平行，尽管程度较小。尽管在老年SCG中显着增加，但主要以“成熟”形式存在的NT-3蛋白在大多数组织中仅表现出较小的变化，尽管NT-3 mRNA通常会降低。相反，虹膜中NT-3转录本和NT-3前体均增加。 proNGF的急剧增加，加上NT-3的最小变化，表明NGF调节的改变可能导致许多老年外周靶标中交感神经的丧失。

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