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首页> 外文期刊>Neurobiology of Aging: Experimental and Clinical Research >Mild cognitive impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly.
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Mild cognitive impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly.

机译：轻度认知障碍（MCI）和实际的检索表现会影响老年人的大脑激活。

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摘要

Cerebral activation in the elderly may depend on general cognitive decline as well as actual retrieval performance. Consequently, activation between subjects with and without Mild Cognitive Impairment (MCI), and between remembered and non-remembered words was compared. Twenty-one MCI and 29 healthy control subjects learned 180 nouns. During retrieval, subjects had to discriminate these and 180 distractor words. fMRI identified response-related activation. Most retrieval-related activation was comparable in both groups. However, MCI subjects showed more activation in the prefrontal cortex than controls during processing of hits and correct rejections. Hits showed increased activation than misses in the precuneus and left lateral parieto-occipital cortex; misses showed more activation than correct rejections in the precuneus to cuneus. Verbal retrieval activated a large common network in the elderly independently of MCI. Increased activation in MCI subjects in prefrontal cortex depends on response category. Activation differences between response categories might reflect success (hits) and effort (misses). Increased retrieval-related activation may be used as early marker in subjects at risk of Alzheimer's disease.
机译：老年人的大脑激活可能取决于一般的认知能力下降以及实际的检索表现。因此，比较了患有和不患有轻度认知障碍（MCI）的受试者之间以及记忆的单词和未记忆的单词之间的激活。 21名MCI和29名健康对照受试者学习了180个名词。在检索过程中，受试者必须区分这180个干扰词。 fMRI确定了与反应相关的激活。两组中大多数与检索有关的激活是可比较的。但是，在击中和正确拒绝的过程中，MCI对象在前额叶皮层中的激活程度高于对照组。命中表现出比前胎和左侧顶枕枕皮层中的遗失激活增加。遗漏显示的激活比对楔形胎前的正确排斥反应的激活更多。言语检索独立于MCI激活了老年人中的大型公共网络。前额叶皮层中MCI受试者激活的增加取决于反应类别。响应类别之间的激活差异可能反映成功（成功）和努力（失败）。增加的与检索有关的激活可以用作处于阿尔茨海默氏病风险中的受试者的早期标志物。

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