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首页> 外文期刊>Neuropsychologia >The 'paradoxical' engagement of the primary auditory cortex in patients with auditory verbal hallucinations: a meta-analysis of functional neuroimaging studies.
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The 'paradoxical' engagement of the primary auditory cortex in patients with auditory verbal hallucinations: a meta-analysis of functional neuroimaging studies.

机译：听觉言语幻觉患者初级听觉皮层的“反常”参与：功能神经影像学研究的荟萃分析。

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The existing literature on neuroimaging studies of auditory verbal hallucinations (AVHs) in patients with schizophrenia contains an apparent "paradox" in that the same areas in the auditory cortex seem to be both activated and deactivated in relation to AVHs, depending on whether an external auditory stimulus is present or not. We performed meta-analyses of neuroimaging studies examining patients with schizophrenia during the processing of auditory stimuli and in individuals experiencing hallucinations in the absence of auditory stimuli to examine whether the auditory cortex shows the paradoxical decrease/increase pattern across studies. Databases PubMed and ISI Web of Knowledge were queried with the combination of the keywords "auditory verbal hallucinations", "auditory hallucinations", "fMRI", "PET", "imaging", yielding 11 studies involving comparison between schizophrenia and control group during external auditory stimulation, and 12 studies of hallucinating subjects experiencing AVHs and resting in the absence of auditory stimulation. The data were analyzed using Activation Likelihood Estimation method. The results showed overlapping increased activation in the absence of an external stimulus, and decreased activation in the presence of an external auditory stimulus in the left primary auditory cortex and in the right rostral prefrontal cortex, confirming the "paradoxical" brain activation in relation to AVHs. It is suggested that the "paradox" may be caused by an attentional bias towards internally generated information and failure of down- and up-regulation of the default mode and auditory processing networks, respectively, with the consequence that the spontaneous activation in the absence of an external stimulus shuts down the perceptual apparatus for further processing.
机译：关于精神分裂症患者的听觉幻觉（AVH）的神经影像学研究的现有文献包含一个明显的“悖论”，即听觉皮层中的相同区域相对于AVHs似乎既激活又失活，这取决于外部听觉刺激是否存在。我们进行了神经影像学研究的荟萃分析，以检查在听觉刺激过程中患有精神分裂症的患者以及在没有听觉刺激的情况下经历幻觉的个体，以检查听觉皮层是否在所有研究中均显示出自相矛盾的减少/增加模式。通过关键词“听觉言语幻觉”，“听觉幻觉”，“ fMRI”，“ PET”，“影像学”的组合查询数据库PubMed和ISI Web of Knowledge，得出11项研究，涉及外部精神分裂症和对照组之间的比较听觉刺激和12项幻觉对象经历AVH并在没有听觉刺激的情况下休息的研究。使用激活可能性估计方法分析数据。结果显示，在没有外部刺激的情况下，重叠的激活增加重叠，而在左侧初级听觉皮层和右额叶前额叶皮层中，在存在外部听觉刺激的情况下，激活减少，这证实了与AVH相关的“悖论性”大脑激活。建议“悖论”可能是由于对内部生成的信息的注意偏见以及默认模式和听觉处理网络的下调和上调失败而导致的，其结果是在不存在自发激活的情况下外部刺激会关闭感知设备以进行进一步处理。

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