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首页> 外文期刊>Neuropsychologia >The neural basis of autobiographical memory deficits in transient epileptic amnesia
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The neural basis of autobiographical memory deficits in transient epileptic amnesia

机译：短暂性癫痫性失忆自传记忆缺陷的神经基础

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摘要

Transient epileptic amnesia (TEA) is a recently recognized form of temporal lobe epilepsy which is often associated with persistent interictal impairment of autobiographical memory. We used fMRI to investigate the neural basis of this deficit. Eleven patients with TEA, who had no significant deficits on standard tests of anterograde memory, and 17 age and IQ matched healthy controls retrieved memories from across the lifespan. Both groups engaged the autobiographical memory network, but activation in patients was less extensive than in controls. Direct comparison revealed hypoactivation of regions in the right hemisphere. Specifically, patients showed reduced activation of the posterior parahippocampal gyrus (pPHG), especially for mid-life and recent memories, with decreased engagement of the right temporoparietal junction and the cerebellum. In addition, we found reduced effective connectivity in patients between the right pPHG and the right middle temporal gyrus. Our results are consistent with other evidence that TEA is a syndrome of medial temporal lobe epilepsy and indicate that it affects the function and connectivity of regions within the autobiographical memory network.
机译：短暂性癫痫性遗忘症（TEA）是颞叶癫痫的一种最近公认的形式，通常与自传体记忆的持续性间质性损伤有关。我们使用功能磁共振成像来研究这种缺陷的神经基础。 11名TEA患者的顺行性记忆标准检查无明显缺陷，并且17位年龄和智商匹配的健康对照者从整个寿命中检索到记忆。两组都参加了自传记忆网络，但是患者的激活程度没有对照组高。直接比较显示右半球区域的激活不足。具体而言，患者显示出后海马旁回（pPHG）的激活减少，特别是在中年和最近的记忆中，而右侧颞顶叶接合处和小脑的接合减少。此外，我们发现右pPHG和右中颞回之间的患者有效连接性降低。我们的结果与TEA是内侧颞叶癫痫综合征的其他证据一致，并表明它影响自传记忆网络内区域的功能和连通性。

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