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首页> 外文期刊>Neuropsychologia >Prefrontal cortex contributions to controlled memory judgment: FMRI evidence from adolescents and young adults
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Prefrontal cortex contributions to controlled memory judgment: FMRI evidence from adolescents and young adults

机译：前额叶皮层对受控记忆判断的贡献：青少年和年轻人的FMRI证据

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Cortical regions supporting cognitive control and memory judgment are structurally immature in adolescents. Here we studied adolescents (13-15 y.o.) and young adults (20-22 y.o.) using a recognition memory paradigm that modulates cognitive control demands through cues that probabilistically forecast memory probe status. Behaviorally, adolescence was associated with quicker responding in the presence of invalid cues compared to young adulthood. fMRI data demonstrated that while both groups increasingly activated posterior dorsolateral prefrontal (dlPFC), midline, and lateral parietal regions for invalidly compared to validly cued trials, this differential invalid cueing response ended sooner in adolescents, consistent with their quicker responding on invalidly cued trials. Critically, dlPFC also demonstrated reversed brain-behavior associations across the groups. Increased mean dlPFC activation during invalid cueing was linked to improved performance in young adults, whereas increases within adolescents were linked to impaired performance. Resting state connectivity analysis revealed greater connectivity between dlPFC and episodic retrieval linked regions in young adults relative to adolescents. These data demonstrate that the functional interpretation of dlPFC activation hinges on its physical maturation and suggest that the pattern of behavioral and neural response in adolescents reflects different functional integration of cognitive control and memory systems.
机译：支持认知控制和记忆判断的皮质区域在青少年中在结构上不成熟。在这里，我们使用识别记忆范式研究了青少年（13-15岁）和年轻人（20-22岁），这些记忆可通过概率预测记忆探针状态的线索来调节认知控制需求。在行为上，与成年年轻人相比，在存在无效线索的情况下，青春期与更快的反应相关。 fMRI数据表明，与有效线索试验相比，两组均越来越多地激活后背外侧前额叶（dlPFC），中线和顶壁外侧区域，但这种差异无效线索提示反应在青少年中更快地结束，这与他们对无效线索试验的响应更快有关。至关重要的是，dlPFC还证明了各组之间的反向大脑行为关联。无效提示期间平均dlPFC激活增加与年轻人的表现改善有关，而青少年内部的增加与表现受损有关。静止状态连通性分析显示，相对于青少年，dlPFC和情节检索链接区域之间的连通性更高。这些数据表明dlPFC激活的功能解释取决于其物理成熟度，并表明青少年的行为和神经反应模式反映了认知控制和记忆系统的不同功能整合。

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