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首页> 外文期刊>Neuropsychobiology >No Evidence for Effects of a High-Frequency Repetitive Transcranial Magnetic Stimulation Series on Verbal and Figural Fluency and TAP Task Performance in Healthy Male Volunteers.
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No Evidence for Effects of a High-Frequency Repetitive Transcranial Magnetic Stimulation Series on Verbal and Figural Fluency and TAP Task Performance in Healthy Male Volunteers.

机译：没有证据表明高频重复经颅磁刺激系列对健康男性志愿者的言语和图形流利度和TAP任务表现有影响。

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摘要

Background: Study results on cognitive effects of repetitive transcranial magnetic stimulation (rTMS) in healthy people are inconsistent. Moreover, former trials performed exclusively single-session stimulations. This sham-controlled study analyzed the influence of 9 serial high-frequency rTMS on cognition. Methods: 44 young healthy male volunteers received active or sham rTMS. We evaluated verbal fluency tasks, the Ruff Figural Fluency Test and different Test for Attentional Performance tasks (alertness, goo-go, divided attention, working memory, flexibility) prior to the first stimulation, immediately (within 5-30 min) after stimulation on day 5 and on day 10 (1 day after the last stimulation). Results: Overall, our statistical analyses revealed no significant cognitive effects of serial rTMS. Conclusion: In this sham-controlled study design, 9 serial rTMS over the left dorsolateral prefrontal cortex (targeted by the 5-cm rule) did neither enhance nor impair the assessed cognitive functions in healthy male volunteers.
机译：背景：重复经颅磁刺激（rTMS）对健康人的认知作用的研究结果不一致。此外，以前的试验仅进行单节刺激。该假对照研究分析了9个串行高频rTMS对认知的影响。方法：44名年轻的健康男性志愿者接受了主动或假rTMS。我们在第一次刺激之前，之后（5-30分钟内）评估了口语流利度任务，Ruff人物形象流利度测试和注意表现任务的不同测试（警觉性，通过/不通过，注意力分散，工作记忆，灵活性）在第5天和第10天（最后一次刺激后的第1天）进行刺激。结果：总的来说，我们的统计分析表明，连续rTMS并没有明显的认知作用。结论：在该假对照研究设计中，在健康的男性志愿者中，左侧背外侧前额叶皮层上的9个连续rTMS（以5 cm规则为目标）既没有增强也没有损害所评估的认知功能。

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