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首页> 外文期刊>Neuropsychologia >Verbal working memory performance correlates with regional white matter structures in the frontoparietal regions.
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Verbal working memory performance correlates with regional white matter structures in the frontoparietal regions.

机译：言语工作记忆表现与额顶区域的区域白质结构相关。

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摘要

Working memory is the limited capacity storage system involved in the maintenance and manipulation of information over short periods of time. Previous imaging studies have suggested that the frontoparietal regions are activated during working memory tasks; a putative association between the structure of the frontoparietal regions and working memory performance has been suggested based on the analysis of individuals with varying pathologies. This study aimed to identify correlations between white matter and individual differences in verbal working memory performance in normal young subjects. We performed voxel-based morphometry (VBM) analyses using T1-weighted structural images as well as voxel-based analyses of fractional anisotropy (FA) using diffusion tensor imaging. Using the letter span task, we measured verbal working memory performance in normal young adult men and women (mean age, 21.7 years, SD=1.44; 42 men and 13 women). We observed positive correlations between working memory performance and regional white matter volume (rWMV) in the frontoparietal regions. In addition, FA was found to be positively correlated with verbal working memory performance in a white matter region adjacent to the right precuneus. These regions are consistently recruited by working memory. Our findings suggest that, among normal young subjects, verbal working memory performance is associated with various regions that are recruited during working memory tasks, and this association is not limited to specific parts of the working memory network.
机译：工作存储器是容量有限的存储系统，在短时间内维护和处理信息。先前的影像学研究表明，在工作记忆任务中，额前额区被激活。根据对具有不同病理的个体的分析，已提出了额顶区域的结构与工作记忆性能之间的推测联系。本研究旨在确定正常年轻人中白质与口头工作记忆表现的个体差异之间的相关性。我们使用T1加权结构图像进行了基于体素的形态学（VBM）分析，并使用扩散张量成像对分数各向异性（FA）进行了基于体素的分析。使用字母跨度任务，我们测量了正常成年男性和女性（平均年龄21.7岁，SD = 1.44; 42名男性和13名女性）的口头工作记忆表现。我们观察到额叶前额区域的工作记忆性能与区域白质体积（rWMV）之间呈正相关。此外，发现FA与邻近右前突的白质区域的口头工作记忆表现呈正相关。这些区域始终由工作记忆招募。我们的研究结果表明，在正常的年轻受试者中，口头工作记忆表现与在工作记忆任务期间招募的各个区域相关，并且这种关联不限于工作记忆网络的特定部分。

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