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首页> 外文期刊>Neuropsychologia >An fMRI study of theory of mind in schizophrenic patients with 'passivity' symptoms.
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An fMRI study of theory of mind in schizophrenic patients with 'passivity' symptoms.

机译：功能性磁共振成像研究精神分裂症患者具有“被动”症状的心理理论。

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Several studies have shown that patients with schizophrenia underactivate brain regions involved in theory of mind relative to controls during functional brain imaging. However, in most studies the samples were fairly heterogeneous in terms of clinical symptomatology. We examined a group of nine patients with first episode or recurrent episodes, who clinically presented with predominant passivity control, using a cartoon-based theory of mind task and compared activation patterns with a group of 13 healthy controls. All patients responded well to antipsychotic treatment and were only mildly symptomatic at the time of testing. The patient group showed significantly less activation of the right anterior cingulate cortex (ACC) and right insula compared with controls, but greater activation in dorsal areas of the medial prefrontal cortex, right temporal areas and left temporo-parietal junction. Patients with schizophrenia with predominant passivity diverging pattern of brain activation during theory of mindtask performance compared with healthy controls. These findings suggest abnormal activation of those brain areas involved in the evaluation of self-reference during mental state attribution.
机译：几项研究表明，精神分裂症患者在功能性脑成像过程中相对于对照而言会失常参与心理理论的大脑区域。但是，在大多数研究中，就临床症状而言，样品的异质性很强。我们使用基于卡通的心理任务理论检查了9名首发或复发发作的患者，这些患者在临床上表现出主要的被动控制能力，并将激活模式与13名健康对照者进行了比较。所有患者对抗精神病药物治疗均反应良好，并且在测试时仅为轻度症状。与对照组相比，患者组的右前扣带回皮层（ACC）和右岛鞘的激活明显较少，但内侧前额叶皮层的背侧区域，右颞侧区域和左颞顶顶交界处的激活程度更高。与健康对照组相比，在心理任务表现理论中精神分裂症患者主要具有被动消散模式的大脑激活模式。这些发现表明，在精神状态归因过程中，参与自我参照评估的大脑区域异常活跃。

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