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首页> 外文期刊>Neuroreport >Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries
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Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries

机译：臂丛神经撕脱伤后对侧第七颈脊髓神经根转移后半球功能重组期间大鼠原发性运动皮层中miR-132，miR-134和miR-485的表达

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摘要

The transfer of a contralateral healthy seventh cervical spinal nerve root (cC7) to the recipient nerve in the injured side is considered a promising procedure for restoration of the physiological functions of an injured hand after brachial plexus root avulsion injury (BPAI). Growing evidence shows that transhemispheric cortical reorganization plays an important role in the functional recovery of the injured arm after cC7 nerve transfer surgery. However, the molecular mechanism underlying the transhemispheric cortical reorganization after cC7 transfer remains elusive. In the present study, we investigated the expression of miR-132, miR-134, and miR-485 in the rat primary motor cortex after cC7 transfer following BPAI by quantitative PCR. The results demonstrated the dynamic alteration in the expression of miR-132, miR-134, and miR-485 in the primary motor cortex of rats after cC7 transfer following BPAI. It indicates that microRNAs are involved in the dynamic transhemispheric functional reorganization after cC7 root transfer following BPAI. Together, this study is the first to provide evidence for the involvement of microRNAs during dynamic transhemispheric functional reorganization after cC7 transfer following BPAI. The results are useful for understanding the mechanism underlying transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following BPAI. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
机译：将对侧健康的第七颈脊髓神经根（cC7）转移到受伤侧的受者神经中，是恢复臂丛神经根撕脱伤（BPAI）后受​​伤手生理功能的有前途的方法。越来越多的证据表明，跨半球皮质重组在cC7神经移植手术后对受伤手臂的功能恢复中起着重要作用。但是，cC7转移后跨半球皮质重组的分子机制仍然难以捉摸。在本研究中，我们通过定量PCR研究了BPAI后cc7转移后大鼠原代运动皮层中miR-132，miR-134和miR-485的表达。结果表明，BPAI后cC7转移后，大鼠原代运动皮层中miR-132，miR-134和miR-485的表达发生了动态变化。这表明在BPAI之后，cC7根转移后，microRNA参与了动态的跨半球功能重组。总之，这项研究是第一个为BPAI之后cC7转移后microRNA在动态跨半球功能重组过程中参与提供证据的证据。该结果有助于了解BPAI后对侧第七颈脊髓神经根转移后跨半球功能重组的机制。版权所有（C）2015 Wolters Kluwer Health，Inc.保留所有权利。

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