Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory?

Koh MT; Bernstein IL

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Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory?

机译：在条件性味觉厌恶恢复过程中抑制蛋白激酶A的活性：干扰记忆的消亡或巩固？

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The involvement of the cAMP-dependent protein kinase A (PKA) signaling pathway in protein synthesis-dependent memory consolidation has been supported by studies of fear conditioning and conditioned taste aversion (CTA). The present experiment examined whether inhibition of PKA activity at the time of memory retrieval impedes or promotes subsequent extinction. When Rp-cAMPS was infused into the amygdala at the time of CTA testing (retrieval), extinction was accelerated. Results confirm recent findings that stored memories become more labile when they are retrieved and extend these findings to CTA memories.

机译：恐惧调节和条件化味觉厌恶（CTA）的研究支持了cAMP依赖性蛋白激酶A（PKA）信号通路参与蛋白质合成依赖性记忆巩固。本实验研究了在记忆检索时抑制PKA活性是阻止还是促进了随后的灭绝。当在CTA测试（取回）时将Rp-cAMPS注入杏仁核时，灭绝加速了。结果证实了最近的发现：存储的存储器在检索时变得更加不稳定，并将这些发现扩展到CTA存储器。

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《Neuroreport》 |2003年第3期|共3页
作者
Koh MT; Bernstein IL;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
Avoidance Learning; Conditioning Psychology physiology; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; 回避学习; 环AMP; 环AMP依赖性蛋白激酶类; 记忆; 味觉;

机译：Avoidance Learning;Conditioning Psychology physiology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;回避学习;环AMP;环AMP依赖性蛋白激酶类;记忆;味觉;

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1. Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory? [J] . Koh MT, Bernstein IL Neuroreport . 2003,第3期

机译：在条件性味觉厌恶恢复过程中抑制蛋白激酶A的活性：干扰记忆的消亡或巩固？
2. The Effects of Protein Kinase Inhibitor Mzeta on Retention and Reconsolidation of Long-Term Memory in Conditioned Food Aversion in Snails [J] . V. P. Nikitin, S. V. Solntseva, S. A. Kozyrev Neuroscience and behavioral physiology . 2016,第3期

机译：蛋白激酶抑制剂Mzeta对蜗牛条件性食物厌恶中长期记忆的保留和巩固的影响
3. Involvement of M zeta-Like Protein Kinase in the Mechanisms of Conditioned Food Aversion Memory Reconsolidation in the Helix lucorum [J] . Bulletin of experimental biology and medicine . 2015,第2期

机译：M zeta样蛋白激酶参与条件性食物厌恶记忆在Helix lucorum中的巩固机制。
4. Neural substrates for the retrieval of conditioned taste aversion revealed by manganese-enhanced MRI [C] . Inui Tadashi, Shimura Tsuyoshi, Yoshioka Yoshichika, World Automation Congress . 2014

机译：锰增强MRI显示的用于恢复条件性味觉厌恶的神经基质
5. Comparison of nutritive and non -nutritive stimuli in the intestinal taste aversion and classical conditioned taste aversion paradigms [D] . Tracy, Andrea L. 2005

机译：肠味厌恶与经典条件性味厌范例中营养性和非营养性刺激的比较
6. Fear memory formation can affect a different memory: fear conditioning affects the extinction but not retrieval of conditioned taste aversion (CTA) memory [O] . Gil Joels, Raphael Lamprecht 2014

机译：恐惧记忆的形成会影响不同的记忆：恐惧条件影响条件味厌恶（CTA）记忆的灭绝但不会恢复
7. Fear memory formation can affect a different memory: fear conditioning affects the extinction, but not retrieval, of conditioned taste aversion (CTA) memory [O] . Gil eJoels, Raphael eLamprecht 2014

机译：恐惧记忆的形成可以影响不同的记忆：恐惧条件影响条件性味觉厌恶（CTa）记忆的灭绝，但不影响
8. Interactions Between Radiation and Amphetamine in Taste Aversion Learning and the Role of the Area Postrema in Amphetamine-Induced Conditioned Taste Aversions [R] . Rabin, B. M., Hunt, W. A., Lee, J. 1987

机译：味觉厌恶学习中辐射与安非他明的相互作用及安非他明诱导的条件性味觉厌恶后区域的作用

Inhibition of protein kinase A activity during conditioned taste aversion retrieval: interference with extinction or reconsolidation of a memory?

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