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首页> 外文期刊>Neuroreport >Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain.
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Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain.

机译：海藻酸可上调小鼠大脑中解偶联蛋白2 mRNA的表达。

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SUMMARY: Intraperitoneal injection of kainic acid (KA) in C57BL/6J and 129T2SvEmsJ mice led to a transient induction of uncoupling protein-2 (Ucp2) mRNA expression in several brain regions, which included the CA1 subfield of the hippocampus, the dorsal endopiriform nucleus and the piriform cortex in both strains. In all those regions, levels of Ucp2 mRNA expression, as determined by in situ hybridization, peaked at 24 h and returned to basal levels within 72 h post-injection. The increase in mRNA expression was mainly observed in neurons, with microglial cells displaying only scattered expression of the gene. The neuronal induction of Ucp2 in response to KA was stronger in 129T2SvEmsJ mice than in C57BL/6J, which suggests a role for Ucp2 in excitotoxic challenges and neuroprotection.
机译：简介：在C57BL / 6J和129T2SvEmsJ小鼠中腹膜内注射海藻酸（KA）导致瞬时诱导几个大脑区域的解偶联蛋白2（Ucp2）mRNA表达，其中包括海马CA1子区，背侧内膜状核和两个菌株的梨状皮层。在所有这些区域中，通过原位杂交确定的Ucp2 mRNA表达水平在24小时达到峰值，并在注射后72小时内恢复至基础水平。 mRNA表达的增加主要在神经元中观察到，小胶质细胞仅显示该基因的分散表达。在129T2SvEmsJ小鼠中，响应KA的Ucp2的神经元诱导作用强于C57BL / 6J，这表明Ucp2在兴奋性毒性攻击和神经保护中发挥作用。

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