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首页> 外文期刊>Neuroreport >Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy.
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Correlation of interictal spike-wave with thalamic glucose metabolism in juvenile myoclonic epilepsy.

机译：幼年肌阵挛性癫痫发作间期尖峰波与丘脑葡萄糖代谢的相关性。

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摘要

The purpose of this study is to define metabolic correlates of generalized spike-wave discharges in juvenile myoclonic epilepsy. We investigated the alterations in glucose metabolism and possible correlations between the interictal epileptiform discharges and regional metabolism in patients with juvenile myoclonic epilepsy using a combined positron emission tomography/electroencephalography method. We found that the thalamic metabolism is slightly increased interictally in the patient group compared with controls. We also observed significant positive correlations between the amount of spike-wave activity and thalamic metabolism. Our results provide evidence that the thalamus has an important role in the generation of spontaneous generalized spike-wave discharges in juvenile myoclonic epilepsy.
机译：这项研究的目的是确定青少年肌阵挛性癫痫中广义尖峰波放电的代谢相关性。我们使用正电子发射断层扫描/脑电图方法研究了青少年肌阵挛性癫痫患者葡萄糖代谢的变化以及发作间期癫痫样放电与区域代谢之间的可能相关性。我们发现与对照组相比，患者组的丘脑代谢略有增加。我们还观察到了尖峰波活动量和丘脑代谢之间的显着正相关。我们的结果提供了证据，证明丘脑在青少年肌阵挛性癫痫的自发性全身性尖峰波放电产生中具有重要作用。

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