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首页> 外文期刊>Neuropsychobiology >Effects of tryptophan depletion on cognitive functioning, obsessive-compulsive symptoms and mood in obsessive-compulsive disorder: preliminary results.
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Effects of tryptophan depletion on cognitive functioning, obsessive-compulsive symptoms and mood in obsessive-compulsive disorder: preliminary results.

机译：色氨酸耗竭对强迫症患者认知功能，强迫症和情绪的影响：初步结果。

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BACKGROUND: Previous studies suggest that obsessive-compulsive disorder (OCD) is associated with moderate cognitive deficits. There is also evidence for altered serotonergic transmission in OCD. The aim of this study was to evaluate the impact of rapid plasma tryptophan depletion on cognitive functioning in OCD. METHODS: A double-blind crossover study was conducted to explore the effects of tryptophan depletion on cognitive functioning, obsessive or compulsive (OC) symptoms and mood in OCD patients treated with selective serotonin reuptake inhibitors. RESULTS: After 5 h of tryptophan depletion, 6 out of 7 patients reported worsening of mood (placebo condition: 3 patients). No effect was found regarding OC symptoms. There was a small and nonsignificant improvement of nonverbal memory and fluency. Problem solving ability and verbal memory, in contrast, were slightly impaired after tryptophan depletion. The results, however, represented only tendencies without reaching significance. CONCLUSION: The results suggest that OC symptoms may not depend on the short-time availability of serotonin. As some critical cognitive functions improved following tryptophan depletion, there is no evidence from our study that neuropsychological impairment in OCD can be reduced to a lowered level of serotonin. Future studies are needed to further clarify these findings by use of larger samples.
机译：背景：先前的研究表明强迫症（OCD）与中度认知缺陷有关。也有证据表明强迫症中血清素能传递的改变。这项研究的目的是评估血浆色氨酸快速耗竭对强迫症患者认知功能的影响。方法：进行了一项双盲交叉研究，以研究色氨酸耗竭对选择性5-羟色胺再摄取抑制剂治疗的强迫症患者认知功能，强迫或强迫症状和情绪的影响。结果：色氨酸耗竭5小时后，每7例患者中就有6例报告情绪恶化（安慰剂：3例）。没有发现有关OC症状的影响。非语言记忆和流利性的改善很小且不显着。相比之下，色氨酸耗竭后，解决问题的能力和口头记忆受到轻微损害。然而，结果仅代表趋势而未达到意义。结论：结果表明OC症状可能不取决于5-羟色胺的短期供应。由于色氨酸耗竭后一些关键的认知功能得到改善，因此我们的研究没有证据表明强迫症中的神经心理学障碍可以降低至血清素水平降低。需要进行进一步的研究，以通过使用较大的样本进一步阐明这些发现。

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